Vincristine
For an informed discussion with your doctor or pharmacist. This information collection is not a clinically validated interaction checker. Missing data do not establish safety. Do not change or stop prescribed medicines on the basis of this information. The findings apply to the specific conditions studied; laboratory and animal studies cannot be directly extrapolated to humans.
Active substance: Vincristine
Examples of brand names: Oncovin [USA; historical example]
ATC code: L01CA02
Main use (for orientation): Oncology
Documented research summary
Transport inhibition and antitumour/neuropathy effects are predominantly preclinical and partly contradictory. CBD case reports with PCV/chemoradiotherapy do not establish a causal vincristine interaction; the ABCC1 experiment is exclusively a laboratory measurement.
Uncertainties and limitations
Intravenous Hospira vincristine sulphate; not liposomal. ABCC1 cell assay separate from label knowledge about P-gp.
Shared enzymes must not be equated with clinical evidence of an interaction; CBD/THC findings cannot be extrapolated to other cannabinoids.
Separately recorded findings
5 separately recorded findings. Each statement applies to its documented study context.
CBD – laboratory and animal studies
Finding ID: B0222
Type of result: Preclinical evidence
Observation: Submicromolar CBD blocked vincristine-induced neuronal sensitisation in an experimental model.
Mechanism: Neuronal sensitisation
Study type: Neuronal model
Context studied: Slow, broadly acting nociceptor inhibition.
Clinical interpretation: Model finding, not a recommendation for use
Limitations and uncertainties: Do not equate with clinically demonstrated neuropathy prevention.
Original sources for this finding: Physiological profiling of cannabidiol reveals profound inhibition of sensory neurons. [BMED38815194]
THC and CBD – laboratory and animal studies
Finding ID: B0223
Type of result: Preclinical evidence
Observation: THC, not CBD alone, reduced mechanical hypersensitivity; a low-dose CBD/THC combination showed no corresponding effect in the vincristine model.
Mechanism: Neuropathic pain behaviour
Study type: Mouse model
Context studied: Substance- and model-dependent negative finding is important.
Clinical interpretation: Model finding, not a recommendation for use
Limitations and uncertainties: No blanket synergy claim.
Original sources for this finding: Single and combined effects of Δ9-tetrahydrocannabinol and cannabidiol in a mouse model of chemotherapy-induced neuropathic pain. [BMED28548225]
CBD or CBD/THC – laboratory and animal studies
Finding ID: B0224
Type of result: Preclinical evidence
Observation: Cell studies showed additive/synergistic effects; treatment sequence was important in leukaemia cells.
Mechanism: Antitumour combination
Study type: Human and canine cell models
Context studied: Canine CBD/vincristine models; CBD/THC pairs in human leukaemia cells; CHOP component study.
Clinical interpretation: Model finding, not a recommendation for use
Limitations and uncertainties: Not a CBDA combination or clinical efficacy; chemotherapy before cannabinoids was better than the reverse order in the model investigated.
Original sources for this finding: The effect of cannabidiol on canine neoplastic cell proliferation and mitogen-activated protein kinase activation during autophagy and apoptosis. [BMED33247539]; Anticancer effects of phytocannabinoids used with chemotherapy in leukaemia cells can be improved by altering the sequence of their administration. [BMED28560402]; Cytotoxicity of Cannabinoids in Combination with Traditional Lymphoma Chemotherapeutic Drugs Against Non-Hodgkin's Lymphoma. [BMED41595541]
Cannabis extracts – laboratory and animal studies
Finding ID: B0225
Type of result: Preclinical evidence
Observation: Extracts showed antinociception in rats; another investigation found increased hippocampal pro-inflammatory markers.
Mechanism: Neuropathy/inflammation
Study type: Rat models
Context studied: Different endpoints and complex products.
Clinical interpretation: Model finding, not a recommendation for use
Limitations and uncertainties: No general neuroprotective effect of all cannabinoids.
Original sources for this finding: Cannabis sativa L. Extract Alleviates Neuropathic Pain and Modulates CB1 and CB2 Receptor Expression in Rat. [BMED39334832]; Cannabis sativa L. Extract Increases COX-1, COX-2 and TNF-α in the Hippocampus of Rats with Neuropathic Pain. [BMED39795254]
CBD – clinical signals
Finding ID: B0226
Type of result: Clinical observation – not causal
Observation: Two glioma cases reported favourable courses with multiple treatments including CBD.
Mechanism: Supportive treatment with PCV
Study type: Two uncontrolled cases
Context studied: Chemoradiotherapy and procarbazine/lomustine/vincristine; MGMT/IDH context.
Clinical interpretation: Context-specific evidence
Limitations and uncertainties: Not an isolated vincristine pair finding or interaction prediction.
Original sources for this finding: Case Report: Clinical Outcome and Image Response of Two Patients With Secondary High-Grade Glioma Treated With Chemoradiation, PCV, and Cannabidiol. [BMED30713832]
References and access status
[V2_LABEL_D0409] VINCRISTINE SULFATE INJECTION, SOLUTION [HOSPIRA, INC.]
Original source / bibliographic reference
Authors: Hospira, Inc.
Year: 2026
Source type: Official US SPL / DailyMed
Source access – 23 October 2026: Source destination was accessible when checked.
Bibliographic attribution or source identity cross-checked.
[BMED38815194] Physiological profiling of cannabidiol reveals profound inhibition of sensory neurons.
Original source / bibliographic reference
Authors: Chahyadinata G, Nam JH, Battenberg A, Wainger BJ.
Year: 2024
Source type: Publication; title and abstract reviewed
DOI: 10.1097/j.pain.0000000000003273
PMID: 38815194
Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.
Bibliographic attribution or source identity cross-checked.
PubMed – bibliographic reference / abstract
PubMed Central – archived text
DOI – publisher access (access restrictions may apply)
[BMED41595541] Cytotoxicity of Cannabinoids in Combination with Traditional Lymphoma Chemotherapeutic Drugs Against Non-Hodgkin's Lymphoma.
Original source / bibliographic reference
Authors: Omer S, Mansour M, Pondugula SR, Dhanasekaran M, Matz B, Khan O, Boothe D.
Year: 2025
Source type: Publication; title and abstract reviewed
DOI: 10.3390/biomedicines14010003
PMID: 41595541
Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.
Bibliographic attribution or source identity cross-checked.
PubMed – bibliographic reference / abstract
PubMed Central – archived text
DOI – publisher access (access restrictions may apply)
[BMED33247539] The effect of cannabidiol on canine neoplastic cell proliferation and mitogen-activated protein kinase activation during autophagy and apoptosis.
Original source / bibliographic reference
Authors: Henry JG, Shoemaker G, Prieto JM, Hannon MB, Wakshlag JJ.
Year: 2021
Source type: Publication; title and abstract reviewed
DOI: 10.1111/vco.12669
PMID: 33247539
Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.
Bibliographic attribution or source identity cross-checked.
PubMed – bibliographic reference / abstract
DOI – publisher access (access restrictions may apply)
[BMED28548225] Single and combined effects of Δ9-tetrahydrocannabinol and cannabidiol in a mouse model of chemotherapy-induced neuropathic pain.
Original source / bibliographic reference
Authors: King KM, Myers AM, Soroka-Monzo AJ, Tuma RF, Tallarida RJ, Walker EA, Ward SJ.
Year: 2017
Source type: Publication; title and abstract reviewed
DOI: 10.1111/bph.13887
PMID: 28548225
Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.
Bibliographic attribution or source identity cross-checked.
PubMed – bibliographic reference / abstract
PubMed Central – archived text
DOI – publisher access (access restrictions may apply)
[BMED39795254] Cannabis sativa L. Extract Increases COX-1, COX-2 and TNF-α in the Hippocampus of Rats with Neuropathic Pain.
Original source / bibliographic reference
Authors: Bartkowiak-Wieczorek J, Jamka M, Kujawski R, Hołysz M, Bienert A, Czora-Poczwardowska K, Szulc M, Mikołajczak P, Bogacz A, Wizner AM, Wielgus K, Słomski R, Mądry E.
Year: 2025
Source type: Publication; title and abstract reviewed
DOI: 10.3390/molecules30010194
PMID: 39795254
Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.
Bibliographic attribution or source identity cross-checked.
PubMed – bibliographic reference / abstract
PubMed Central – archived text
DOI – publisher access (access restrictions may apply)
[BMED39334832] Cannabis sativa L. Extract Alleviates Neuropathic Pain and Modulates CB1 and CB2 Receptor Expression in Rat.
Original source / bibliographic reference
Authors: Bartkowiak-Wieczorek J, Bienert A, Czora-Poczwardowska K, Kujawski R, Szulc M, Mikołajczak P, Wizner AM, Jamka M, Hołysz M, Wielgus K, Słomski R, Mądry E.
Year: 2024
Source type: Publication; title and abstract reviewed
DOI: 10.3390/biom14091065
PMID: 39334832
Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.
Bibliographic attribution or source identity cross-checked.
PubMed – bibliographic reference / abstract
PubMed Central – archived text
DOI – publisher access (access restrictions may apply)
[BMED30713832] Case Report: Clinical Outcome and Image Response of Two Patients With Secondary High-Grade Glioma Treated With Chemoradiation, PCV, and Cannabidiol.
Original source / bibliographic reference
Authors: Dall'Stella PB, Docema MFL, Maldaun MVC, Feher O, Lancellotti CLP.
Year: 2018
Source type: Publication; title and abstract reviewed
DOI: 10.3389/fonc.2018.00643
PMID: 30713832
Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.
Bibliographic attribution or source identity cross-checked.
PubMed – bibliographic reference / abstract
PubMed Central – archived text
DOI – publisher access (access restrictions may apply)
[BMED28560402] Anticancer effects of phytocannabinoids used with chemotherapy in leukaemia cells can be improved by altering the sequence of their administration.
Original source / bibliographic reference
Authors: Scott KA, Dalgleish AG, Liu WM.
Year: 2017
Source type: Publication; title and abstract reviewed
DOI: 10.3892/ijo.2017.4022
PMID: 28560402
Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.
Bibliographic attribution or source identity cross-checked.
PubMed – bibliographic reference / abstract
DOI – publisher access (access restrictions may apply)
[BMED18619955] Interaction of plant cannabinoids with the multidrug transporter ABCC1 (MRP1).
Original source / bibliographic reference
Authors: Holland ML, Allen JD, Arnold JC.
Year: 2008
Source type: Publication; title and abstract reviewed
DOI: 10.1016/j.ejphar.2008.06.079
PMID: 18619955
Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.
Bibliographic attribution or source identity cross-checked.
PubMed – bibliographic reference / abstract
DOI – publisher access (access restrictions may apply)
Research as of 23 October 2026. Not all original full texts could be reviewed in full. Source accessibility and the strength of scientific evidence must be assessed separately. An accessible link does not establish medical approval; a bibliographic record with an abstract does not replace the original full text.
Drug search and explanation of the evidence · Guide: cannabinoids and medicines · Author and responsibility
Vincristine and cannabinoids: documented findings, evidence, sources and data gaps. Research information for discussion with your doctor or pharmacist.