Tizanidine

For an informed discussion with your doctor or pharmacist. This information collection is not a clinically validated interaction checker. Missing data do not establish safety. Do not change or stop prescribed medicines on the basis of this information. The findings apply to the specific conditions studied; laboratory and animal studies cannot be directly extrapolated to humans.

Active substance: Tizanidine

Examples of brand names: Sirdalud [DE]

ATC code: M03BX02

Main use (for orientation): Spasticity

Documented research summary

Nabiximols with mixed antispastic medicines does not isolate tizanidine. Fluvoxamine effects are not adopted as cannabinoid values.

Uncertainties and limitations

Do not transfer fluvoxamine/ciprofloxacin effect sizes to CBD; distinguish cannabis smoke from isolated CBD. Absence of a pair-specific finding does not establish absence of risk.

Research is limited to the specified date and protocol; it is not globally exhaustive. Brand names and authorisations do not constitute a complete current market overview.

Structured assessment

Category: Theoretical context

Cannabinoid scope: 28 register names in the documented search family; neither 28 individual clinical trials nor a blanket assessment of all cannabinoids.

Evidence status: Theoretical plausibility; no verified clinical pair effect

Mechanism / drug context: Tizanidine: CYP1A2, sedation/hypotension.

Type of supporting material: Medicine information and documented individual review; no positive pair trial

Clinical interpretation: Requires individual assessment by a doctor or pharmacist. Lack of evidence does not establish safety; no dosage or discontinuation advice is provided.

Context: Tizanidine hydrochloride, active alpha-2 agonist; oral ONTRALFY solution, not a prodrug. Consider product-specific food effects.

Drug context and gaps in search results are not measured interactions. The source role below describes which statement the source actually supports.

Source role [CA_L_D0177]: Drug context

Statement supported: Supports dosage form, metabolism and/or known risks; alone, it does not substantiate a cannabinoid–drug pair finding.

Source: ONTRALFY (TIZANIDINE HYDROCHLORIDE) SOLUTION [ROSEMONT PHARMACEUTICALS, LLC] [CA_L_D0177]

Source role [CA_P_39106541]: Scope distinction / context

Statement supported: Nabiximols add-on with mixed antispastic medicines, no isolated tizanidine result.

Source: A randomized, double-blind, placebo-controlled trial to evaluate the effect of nabiximols oromucosal spray on clinical measures of spasticity in patients with multiple sclerosis. [CA_P_39106541]

Scope of review: Individual research with documented title/abstract screening and targeted review of original sections. This is not exhaustive evidence that interactions are absent.

Unresolved source question: The complete stored individual review, label review, literature screening, conclusion and uncertainties were read. Targeted sections of original information were rechecked; no claim is made that all product information or full texts were completely revalidated.

Separately recorded findings

No separately substantiated finding for this drug–cannabinoid pair is recorded within the documented scope of review. This does not prove that no such study exists anywhere or that the combination is safe.

References and access status

[CA_L_D0177] ONTRALFY (TIZANIDINE HYDROCHLORIDE) SOLUTION [ROSEMONT PHARMACEUTICALS, LLC]

Original source / bibliographic reference

Authors: Rosemont Pharmaceuticals, LLC

Year: 2025

Source type: Official human-use SPL / DailyMed

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

[CA_P_39106541] A randomized, double-blind, placebo-controlled trial to evaluate the effect of nabiximols oromucosal spray on clinical measures of spasticity in patients with multiple sclerosis.

Original source / bibliographic reference

Authors: Bethoux FA, Farrell R, Checketts D, Sahr N, Berwaerts J, Alexander JK, Skobieranda F.

Year: 2024

Source type: Primary / secondary publication; design and use described in the individual review

DOI: 10.1016/j.msard.2024.105740

PMID: 39106541

Source access – 23 October 2026: Direct retrieval could not be fully verified; availability remains unresolved.

Bibliographic attribution or source identity cross-checked.

DOI – publisher access (access restrictions may apply)

Research as of 23 October 2026. Not all original full texts could be reviewed in full. Source accessibility and the strength of scientific evidence must be assessed separately. An accessible link does not establish medical approval; a bibliographic record with an abstract does not replace the original full text.

Drug search and explanation of the evidence · Guide: cannabinoids and medicines · Author and responsibility