Tenofovir alafenamide

For an informed discussion with your doctor or pharmacist. This information collection is not a clinically validated interaction checker. Missing data do not establish safety. Do not change or stop prescribed medicines on the basis of this information. The findings apply to the specific conditions studied; laboratory and animal studies cannot be directly extrapolated to humans.

Active substance: Tenofovir alafenamide

Examples of brand names: Vemlidy [EU/DE]

ATC code: J05AF13

Main use (for orientation): Hepatitis B; HIV in combination therapy

Documented research summary

Altered CB1 expression in a gp120 model is neither cannabinoid administration nor clinical pair evidence. Missing data do not establish safety.

Uncertainties and limitations

The 28 cannabinoid names in the register define the search scope, not 28 clinically studied pairs. Missing data do not establish safety.

No complete new systematic literature search and no independent medical or pharmaceutical professional approval. Note the dosage form and the country of authorisation of the product information.

Consider activation in different cell types and distinguish from TDF.

Structured assessment

Category: Drug context

Cannabinoid scope: 28 register names within the documented search scope; no newly established direct finding for the target cannabinoid–drug pair. This must not be equated with 28 clinically studied combinations.

Evidence status: Drug properties from regulatory product information; insufficient data for a direct cannabinoid–drug pair finding in the material assessed.

Mechanism / drug context: Activation by cathepsin A and CES1 among other pathways; P-gp/BCRP and, to a lesser extent, CYP3A are relevant.

Type of supporting material: Targeted product-information review and documented individual literature screening; no newly verified direct cannabinoid–drug pair study.

Clinical interpretation: The clinical relevance of a specific cannabinoid combination has not been determined. Drug context may warrant individual professional review, but neither a blanket warning level nor an assurance of safety.

Context: Consider activation in different cell types and distinguish from TDF.

Drug context and gaps in search results are not measured interactions. The source role below describes which statement the source actually supports.

Source role [VE_LABEL_D0331]: Medicine information: properties of the active substance

Statement supported: Activation by cathepsin A and CES1 among other pathways; P-gp/BCRP and, to a lesser extent, CYP3A are relevant. Product information: drug context, not evidence for a specific cannabinoid pair or proof of safety.

Source: VEMLIDY (TENOFOVIR ALAFENAMIDE) TABLET [GILEAD SCIENCES, INC.] [VE_LABEL_D0331]

Source role [VE_MED_37801175]: Screened search result: no established pair evidence

Statement supported: TAF/gp120 alter CB1 receptor expression in mice; no exogenous target cannabinoid administered.

Source: GP120 and tenofovir alafenamide alter cannabinoid receptor 1 expression in hippocampus of mice. [VE_MED_37801175]

Source role [VE_MED_38177832]: Screened search result: no established pair evidence

Statement supported: Correction to the TAF/gp120 receptor-expression paper; not a separate cannabinoid pair study.

Source: Correction: GP120 and tenofovir alafenamide alter cannabinoid receptor 1 expression in hippocampus of mice. [VE_MED_38177832]

Source role [C_PROTOCOL_D0331]: Documented search result

Statement supported: Documented title/abstract search scope for the active substance. The link displays the reproducible search query, not a study or proof that no interaction exists. Search date: 23 October 2026. Further search runs are documented in the research dataset.

Source: Reproducible literature search strategy: Tenofoviralafenamid [C_PROTOCOL_D0331]

Scope of review: Individual research with documented title/abstract screening and targeted review of original sections. This is not exhaustive evidence that interactions are absent.

Unresolved source question: The existing individual review, label review and literature screening were read in full; targeted original PK/interaction passages were checked again, but not all product information and search results were newly reviewed in full text. Search findings are limited to the documented V5 search runs. The linked excluded search result was rechecked using its archived abstract or correction metadata record; this does not imply complete new access to the full text.

Separately recorded findings

No separately substantiated finding for this drug–cannabinoid pair is recorded within the documented scope of review. This does not prove that no such study exists anywhere or that the combination is safe.

References and access status

[VE_LABEL_D0331] VEMLIDY (TENOFOVIR ALAFENAMIDE) TABLET [GILEAD SCIENCES, INC.]

Original source / bibliographic reference

Authors: Respective marketing authorisation holder; regulatory product information

Year: 2025

Source type: Product information / SmPC / US Prescribing Information

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

[VE_MED_37801175] GP120 and tenofovir alafenamide alter cannabinoid receptor 1 expression in hippocampus of mice.

Original source / bibliographic reference

Authors: Kulbe JR, Le AA, Mante M, Florio J, Laird AE, Swinton MK, Rissman RA, Fields JA.

Year: 2023

Source type: research-article; Journal Article; Research Support, N.I.H., Extramural

DOI: 10.1007/s13365-023-01155-x

PMID: 37801175

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

PubMed – bibliographic reference / abstract

[VE_MED_38177832] Correction: GP120 and tenofovir alafenamide alter cannabinoid receptor 1 expression in hippocampus of mice.

Original source / bibliographic reference

Authors: Kulbe JR, Le AA, Mante M, Florio J, Laird AE, Swinton MK, Rissman RA, Fields JA.

Year: 2024

Source type: Published Erratum; correction

DOI: 10.1007/s13365-023-01192-6

PMID: 38177832

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

PubMed – bibliographic reference / abstract

[C_PROTOCOL_D0331] Reproducible literature search strategy: Tenofoviralafenamid

Original source / bibliographic reference

Authors: Europe PMC; documented search run

Year: 2026

Source type: Search strategy / screening protocol – not an individual study

Source access – 23 October 2026: Research protocol with machine-readable search results – not an individual study.

Research as of 23 October 2026. Not all original full texts could be reviewed in full. Source accessibility and the strength of scientific evidence must be assessed separately. An accessible link does not establish medical approval; a bibliographic record with an abstract does not replace the original full text.

Drug search and explanation of the evidence · Guide: cannabinoids and medicines · Author and responsibility