Temsirolimus

For an informed discussion with your doctor or pharmacist. This information collection is not a clinically validated interaction checker. Missing data do not establish safety. Do not change or stop prescribed medicines on the basis of this information. The findings apply to the specific conditions studied; laboratory and animal studies cannot be directly extrapolated to humans.

Active substance: Temsirolimus

Examples of brand names: Torisel [EU/DE]

ATC code: L01EG01

Main use (for orientation): Selected cancers

Documented research summary

Temsirolimus altered selected THC-related memory/motor effects in mice. No clinical pharmacokinetic interaction established; do not equate active sirolimus exposure with temsirolimus.

Uncertainties and limitations

Intravenous Almaject temsirolimus; not oral sirolimus or everolimus. Do not derive cannabinoid pharmacokinetics from their clinical data.

Shared enzymes must not be equated with clinical evidence of an interaction; CBD/THC findings cannot be extrapolated to other cannabinoids.

Separately recorded findings

1 separately recorded finding. Each statement applies to its documented study context.

THC – laboratory and animal studies

Finding ID: B0237

Type of result: Preclinical evidence

Observation: Temsirolimus prevented selected THC memory/anxiety effects and corrected THC-induced motor-coordination impairment in mice.

Mechanism: mTOR/autophagy

Study type: Mouse models

Context studied: Other THC endpoints did not respond; treatment after chronic THC cessation did not reverse the residual deficit.

Clinical interpretation: Context-specific finding, not a recommendation for use

Limitations and uncertainties: No clinical recommendation of a THC antidote or pharmacokinetic AUC prediction.

Original sources for this finding: Dissociation of the pharmacological effects of THC by mTOR blockade. [BMED23358238]; Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination. [BMED32773031]

References and access status

[V2_LABEL_D0446] TEMSIROLIMUS (TEMSIROLIMUS INJECTION) KIT [ALMAJECT, INC.]

Original source / bibliographic reference

Authors: Almaject, Inc.

Year: 2025

Source type: Official US SPL / DailyMed

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

[BMED23358238] Dissociation of the pharmacological effects of THC by mTOR blockade.

Original source / bibliographic reference

Authors: Puighermanal E, Busquets-Garcia A, Gomis-González M, Marsicano G, Maldonado R, Ozaita A.

Year: 2013

Source type: Publication; title and abstract reviewed

DOI: 10.1038/npp.2013.31

PMID: 23358238

Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.

Bibliographic attribution or source identity cross-checked.

PubMed – bibliographic reference / abstract

PubMed Central – archived text

DOI – publisher access (access restrictions may apply)

[BMED32773031] Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination.

Original source / bibliographic reference

Authors: Blázquez C, Ruiz-Calvo A, Bajo-Grañeras R, Baufreton JM, Resel E, Varilh M, Pagano Zottola AC, Mariani Y, Cannich A, Rodríguez-Navarro JA, Marsicano G, Galve-Roperh I, Bellocchio L, Guzmán M.

Year: 2020

Source type: Publication; title and abstract reviewed

DOI: 10.7554/elife.56811

PMID: 32773031

Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.

Bibliographic attribution or source identity cross-checked.

PubMed – bibliographic reference / abstract

PubMed Central – archived text

DOI – publisher access (access restrictions may apply)

Research as of 23 October 2026. Not all original full texts could be reviewed in full. Source accessibility and the strength of scientific evidence must be assessed separately. An accessible link does not establish medical approval; a bibliographic record with an abstract does not replace the original full text.

Drug search and explanation of the evidence · Guide: cannabinoids and medicines · Author and responsibility