Sulpiride

For an informed discussion with your doctor or pharmacist. This information collection is not a clinically validated interaction checker. Missing data do not establish safety. Do not change or stop prescribed medicines on the basis of this information. The findings apply to the specific conditions studied; laboratory and animal studies cannot be directly extrapolated to humans.

Active substance: Sulpiride

Examples of brand names: Dogmatil [DE]

ATC code: N05AL01

Main use (for orientation): Schizophrenia

Documented research summary

No clinical pharmacokinetic interaction found. Sulpiride influences THC and CBD endpoints in animal models; CBD results depend on brain region and the phase of the addiction model investigated. Findings do not establish a combination-treatment recommendation. Renal excretion weakens purely CYP-based hypotheses; additive CNS, orthostatic and QT risks remain separate theoretical considerations.

Uncertainties and limitations

Does not establish safety for less-studied cannabinoids or untested formulations/doses.

Do not infer clinical dosage from preclinical effects or enzyme hypotheses.

Separately recorded findings

3 separately recorded findings. Each statement applies to its documented study context.

CBD – laboratory and animal studies

Finding ID: B0356

Type of result: Preclinical

Observation: Locally administered sulpiride abolished CBD effects on methamphetamine preference/seeking in several brain regions; in the nucleus accumbens, CBD effects on extinction/reinstatement persisted despite D2 blockade in one study.

Mechanism: D2 receptor probe in a rat addiction model

Study type: Animal experiments

Context studied: Rats, local intracerebral antagonist administration; region- and phase-specific primary studies.

Clinical interpretation: Not clinically validated

Limitations and uncertainties: Not an oral human interaction; do not simplify positive and negative D2 findings into universal antagonism.

Original sources for this finding: Modulatory function of cannabidiol on the extinction and reinstatement of methamphetamine-seeking behavior through the D2-like dopamine receptors in the dentate gyrus. [C_PR_41110614]; Cannabidiol mechanism of action on modulating extinction and reinstatement of methamphetamine-seeking behavior: Targeting D2-like dopamine receptors in the hippocampus. [C_PR_40517676]; Cannabidiol Plays a Modulatory Function on the Methamphetamine-Induced Reward Through Hippocampal D2-Like Dopamine Receptors. [C_PR_39540967]; Involvement of D2-like dopamine receptors within the ventral tegmental area in the cannabidiol's inhibitory effects on the methamphetamine-seeking behavior. [C_PR_39961426]; Intra-Accumbal D1- But not D2-Like Dopamine Receptor Antagonism Reverses the Inhibitory Effects of Cannabidiol on Extinction and Reinstatement of Methamphetamine Seeking Behavior in Rats. [C_PR_36048545]; Cannabidiol modulates the METH-induced conditioned place preference through D2-like dopamine receptors in the hippocampal CA1 region. [C_PR_33862125]; Cannabidiol impairs the rewarding effects of methamphetamine: Involvement of dopaminergic receptors in the nucleus accumbens. [C_PR_34662693]

THC – laboratory and animal studies

Finding ID: B0357

Type of result: Preclinical

Observation: Sulpiride 10/100 µM reduced stereotyped circular swimming induced by THC 1 µM in zebrafish.

Mechanism: Dopaminergic pharmacodynamic modulation

Study type: Animal experiments

Context studied: 8 animals per combination, 20-minute water exposure; racemic sulpiride.

Clinical interpretation: Not clinically validated

Limitations and uncertainties: Model endpoint without a confirmed counterpart in human psychosis; no clinical dose extrapolation.

Original sources for this finding: THC-induced behavioral stereotypy in zebrafish as a model of psychosis-like behavior. [C_PR_34344922]

THC – laboratory and animal studies

Finding ID: B0358

Type of result: Preclinical

Observation: S(-)-sulpiride blocked THC-induced hypothermia, memory/acetylcholine changes or antinociception in rat studies; racemic sulpiride did not enhance THC hypothermia in the mouse model.

Mechanism: D2-dependent pharmacodynamic endpoints

Study type: Animal experiments

Context studied: Different species, enantiomers, doses and endpoints; abstracts.

Clinical interpretation: Not clinically validated

Limitations and uncertainties: No combined clinical efficacy/safety conclusion; PMC1572179 inaccessible.

Original sources for this finding: Permissive role of dopamine D(2) receptors in the hypothermia induced by delta(9)-tetrahydrocannabinol in rats. [C_PR_10837859]; D(2) dopamine receptors enable delta(9)-tetrahydrocannabinol induced memory impairment and reduction of hippocampal extracellular acetylcholine concentration. [C_PR_10903956]; Dopamine D(2) receptor antagonists prevent delta(9)-tetrahydrocannabinol-induced antinociception in rats. [C_PR_10611435]; The hypothermic response of mice to delta-9-tetrahydrocannabinol is enhanced by chlorpromazine, thioxanthenes, alpha-adrenoceptor antagonists and pentolinium but not by SCH 23390 or sulpiride. [C_PR_2895430]

References and access status

[C_LABEL_D0129_UK] Sulpiride Grindeks 200 mg Tablets – SmPC

Original source / bibliographic reference

Authors: AS Grindeks

Year: 2022

Source type: UK SmPC

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

[C_PR_41110614] Modulatory function of cannabidiol on the extinction and reinstatement of methamphetamine-seeking behavior through the D2-like dopamine receptors in the dentate gyrus.

Original source / bibliographic reference

Authors: Azizbeigi R, Baharlouei N, Nazari-Serenjeh F, Taslimi Z, Haghparast A.

Year: 2026

Source type: Primary source, abstract read

DOI: 10.1016/j.bbr.2025.115882

PMID: 41110614

Source access – 23 October 2026: Direct retrieval could not be fully verified; availability remains unresolved.

Bibliographic attribution or source identity cross-checked.

DOI – publisher access (access restrictions may apply)

[C_PR_40517676] Cannabidiol mechanism of action on modulating extinction and reinstatement of methamphetamine-seeking behavior: Targeting D2-like dopamine receptors in the hippocampus.

Original source / bibliographic reference

Authors: Omidiani SE, Mohammadi M, Seddighfar M, Azizbeigi R, Haghparast A.

Year: 2025

Source type: Primary source, abstract read

DOI: 10.1016/j.jpsychires.2025.06.011

PMID: 40517676

Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.

Bibliographic attribution or source identity cross-checked.

DOI – publisher access (access restrictions may apply)

[C_PR_39540967] Cannabidiol Plays a Modulatory Function on the Methamphetamine-Induced Reward Through Hippocampal D2-Like Dopamine Receptors.

Original source / bibliographic reference

Authors: Mohammadi M, Omidiani SE, Azizbeigi R, Haghparast A.

Year: 2024

Source type: Primary source, abstract read

DOI: 10.1007/s11064-024-04256-z

PMID: 39540967

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

DOI – publisher access (access restrictions may apply)

[C_PR_39961426] Involvement of D2-like dopamine receptors within the ventral tegmental area in the cannabidiol's inhibitory effects on the methamphetamine-seeking behavior.

Original source / bibliographic reference

Authors: Ezzati MJ, Ezzati MR, Fattahi M, Azizbeigi R, Haghparast A.

Year: 2025

Source type: Primary source, abstract read

DOI: 10.1016/j.physbeh.2025.114845

PMID: 39961426

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

DOI – publisher access (access restrictions may apply)

[C_PR_36048545] Intra-Accumbal D1- But not D2-Like Dopamine Receptor Antagonism Reverses the Inhibitory Effects of Cannabidiol on Extinction and Reinstatement of Methamphetamine Seeking Behavior in Rats.

Original source / bibliographic reference

Authors: Mirmohammadi M, Eskandari K, Koruji M, Shabani R, Ahadi R, Haghparast A.

Year: 2024

Source type: Primary source, abstract read

DOI: 10.1089/can.2022.0017

PMID: 36048545

Source access – 23 October 2026: Direct retrieval could not be fully verified; availability remains unresolved.

Bibliographic attribution or source identity cross-checked.

DOI – publisher access (access restrictions may apply)

[C_PR_34344922] THC-induced behavioral stereotypy in zebrafish as a model of psychosis-like behavior.

Original source / bibliographic reference

Authors: Dahlén A, Zarei M, Melgoza A, Wagle M, Guo S.

Year: 2021

Source type: Primary source, full text read

DOI: 10.1038/s41598-021-95016-4

PMID: 34344922

Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.

Bibliographic attribution or source identity cross-checked.

PubMed – bibliographic reference / abstract

PubMed Central – archived text

DOI – publisher access (access restrictions may apply)

[C_PR_33862125] Cannabidiol modulates the METH-induced conditioned place preference through D2-like dopamine receptors in the hippocampal CA1 region.

Original source / bibliographic reference

Authors: Hassanlou AA, Jamali S, RayatSanati K, Mousavi Z, Haghparast A.

Year: 2021

Source type: Primary source, abstract read

DOI: 10.1016/j.brainresbull.2021.04.007

PMID: 33862125

Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.

Bibliographic attribution or source identity cross-checked.

DOI – publisher access (access restrictions may apply)

[C_PR_34662693] Cannabidiol impairs the rewarding effects of methamphetamine: Involvement of dopaminergic receptors in the nucleus accumbens.

Original source / bibliographic reference

Authors: Sharifi A, Karimi-Haghighi S, Shabani R, Asgari HR, Ahadi R, Haghparast A.

Year: 2022

Source type: Primary source, abstract read

DOI: 10.1016/j.pnpbp.2021.110458

PMID: 34662693

Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.

Bibliographic attribution or source identity cross-checked.

DOI – publisher access (access restrictions may apply)

[C_PR_10837859] Permissive role of dopamine D(2) receptors in the hypothermia induced by delta(9)-tetrahydrocannabinol in rats.

Original source / bibliographic reference

Authors: Nava F, Carta G, Gessa GL.

Year: 2000

Source type: Primary source, abstract read

DOI: 10.1016/s0091-3057(00)00231-8

PMID: 10837859

Source access – 23 October 2026: Direct retrieval could not be fully verified; availability remains unresolved.

Bibliographic attribution or source identity cross-checked.

DOI – publisher access (access restrictions may apply)

[C_PR_2895430] The hypothermic response of mice to delta-9-tetrahydrocannabinol is enhanced by chlorpromazine, thioxanthenes, alpha-adrenoceptor antagonists and pentolinium but not by SCH 23390 or sulpiride.

Original source / bibliographic reference

Authors: Pertwee RG, Hedley D, McQueen AS, Gentleman SM.

Year: 1988

Source type: Primary source, abstract read

DOI: 10.1016/0028-3908(88)90164-5

PMID: 2895430

Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.

Bibliographic attribution or source identity cross-checked.

DOI – publisher access (access restrictions may apply)

[C_PR_10903956] D(2) dopamine receptors enable delta(9)-tetrahydrocannabinol induced memory impairment and reduction of hippocampal extracellular acetylcholine concentration.

Original source / bibliographic reference

Authors: Nava F, Carta G, Battasi AM, Gessa GL.

Year: 2000

Source type: Primary source, abstract read

DOI: 10.1038/sj.bjp.0703413

PMID: 10903956

Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.

Bibliographic attribution or source identity cross-checked.

PubMed – bibliographic reference / abstract

PubMed Central – archived text

DOI – publisher access (access restrictions may apply)

[C_PR_10611435] Dopamine D(2) receptor antagonists prevent delta(9)-tetrahydrocannabinol-induced antinociception in rats.

Original source / bibliographic reference

Authors: Carta G, Gessa GL, Nava F.

Year: 1999

Source type: Primary source, abstract read

DOI: 10.1016/s0014-2999(99)00696-2

PMID: 10611435

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

DOI – publisher access (access restrictions may apply)

Research as of 23 October 2026. Not all original full texts could be reviewed in full. Source accessibility and the strength of scientific evidence must be assessed separately. An accessible link does not establish medical approval; a bibliographic record with an abstract does not replace the original full text.

Drug search and explanation of the evidence · Guide: cannabinoids and medicines · Author and responsibility