Spironolactone

For an informed discussion with your doctor or pharmacist. This information collection is not a clinically validated interaction checker. Missing data do not establish safety. Do not change or stop prescribed medicines on the basis of this information. The findings apply to the specific conditions studied; laboratory and animal studies cannot be directly extrapolated to humans.

Active substance: Spironolactone

Examples of brand names: Aldactone [DE]

ATC code: C03DA01

Main use (for orientation): Heart failure; hyperaldosteronism

Documented research summary

Within the documented search scope, no sufficiently attributable cannabinoid pair is established for Spironolactone. The structured assessment distinguishes documented drug context from the absence of specific interaction evidence. Missing data do not establish safety.

Uncertainties and limitations

Active metabolites and multiple medicines prevent simple conclusions about the parent substance. Do not independently change prescribed medicines on the basis of this research dataset.

Structured assessment

Category: Drug context

Cannabinoid scope: No specifically substantiated pair involving a registered cannabinoid in the material assessed; no claim that all 28 cannabinoids were comprehensively reviewed simultaneously.

Evidence status: Drug properties supported by product information; insufficient evidence for a specific cannabinoid–drug pair effect.

Mechanism / drug context: Formation of active metabolites, including canrenone and sulphur-containing metabolites; potassium-sparing.

Type of supporting material: Product information and documented individual literature screening; no clinical pair trial approved for use as evidence.

Clinical interpretation: No additional cannabinoid-related change in potassium or blood pressure established.

Context: Hormone-related cases involving multiple medicines provide no isolated spironolactone–cannabinoid evidence.

Drug context and gaps in search results are not measured interactions. The source role below describes which statement the source actually supports.

Source role [VD_LABEL_D0229]: Original product information: drug context, not evidence for a cannabinoid–drug pair

Statement supported: Formation of active metabolites, including canrenone and sulphur-containing metabolites; potassium-sparing.

Source: SPIRONOLACTONE (SPIRONOLACTONE) TABLET, FILM COATED [CAMBER PHARMACEUTICALS, INC.] – DailyMed SPL [VD_LABEL_D0229]

Source role [VD_MED_34553162]: Documented research / scope-distinction context; no cannabinoid–drug pair evidence approved for use

Statement supported: Hormone-related cases involving multiple medicines provide no isolated spironolactone–cannabinoid evidence.

Source: The effect of estrogen therapy on spermatogenesis in transgender women. [VD_MED_34553162]

Source role [VD_MED_8094898]: Documented research / scope-distinction context; no cannabinoid–drug pair evidence approved for use

Statement supported: Hormone-related cases involving multiple medicines provide no isolated spironolactone–cannabinoid evidence.

Source: Drug-induced gynecomastia. [VD_MED_8094898]

Scope of review: Individual research with documented title/abstract screening and targeted review of original sections. This is not exhaustive evidence that interactions are absent.

Unresolved source question: All individual review fields read. Original product information was rechecked only in the relevant pharmacokinetic/interaction excerpts; no complete recertification of all labels or worldwide full-text search. Literature access was based on the previously documented review; only the listed web sources were additionally read in this round. Active metabolites and multiple medicines prevent simple conclusions about the parent substance.

Separately recorded findings

No separately substantiated finding for this drug–cannabinoid pair is recorded within the documented scope of review. This does not prove that no such study exists anywhere or that the combination is safe.

References and access status

[VD_LABEL_D0229] SPIRONOLACTONE (SPIRONOLACTONE) TABLET, FILM COATED [CAMBER PHARMACEUTICALS, INC.] – DailyMed SPL

Original source / bibliographic reference

Authors: Marketing authorisation holder / label provider according to the linked DailyMed product information

Year: 2026

Source type: Regulatory product information (US SPL)

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

[VD_MED_34553162] The effect of estrogen therapy on spermatogenesis in transgender women.

Original source / bibliographic reference

Authors: Sinha A, Mei L, Ferrando C.

Year: 2021

Source type: research-article; Journal Article

DOI: 10.1016/j.xfre.2021.06.002

PMID: 34553162

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

PubMed – bibliographic reference / abstract

[VD_MED_8094898] Drug-induced gynecomastia.

Original source / bibliographic reference

Authors: Thompson DF, Carter JR.

Year: 1993

Source type: Review; Journal Article

DOI: 10.1002/phar.1138

PMID: 8094898

Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.

Bibliographic attribution or source identity cross-checked.

PubMed – bibliographic reference / abstract

Research as of 23 October 2026. Not all original full texts could be reviewed in full. Source accessibility and the strength of scientific evidence must be assessed separately. An accessible link does not establish medical approval; a bibliographic record with an abstract does not replace the original full text.

Drug search and explanation of the evidence · Guide: cannabinoids and medicines · Author and responsibility