Salbutamol

For an informed discussion with your doctor or pharmacist. This information collection is not a clinically validated interaction checker. Missing data do not establish safety. Do not change or stop prescribed medicines on the basis of this information. The findings apply to the specific conditions studied; laboratory and animal studies cannot be directly extrapolated to humans.

Active substance: Salbutamol

Examples of brand names: Sultanol [DE]

ATC code: R03AC02

Main use (for orientation): Asthma; COPD

Documented research summary

THC/salbutamol comparisons and cannabis cohorts do not establish a salbutamol–THC interaction. Missing data do not establish safety.

Uncertainties and limitations

The 28 cannabinoid names in the register define the search scope, not 28 clinically studied pairs. Missing data do not establish safety.

No complete new systematic literature search and no independent medical or pharmaceutical professional approval. Note the dosage form and the country of authorisation of the product information.

Historical bronchodilator comparisons are not combined-exposure experiments.

Structured assessment

Category: Evidence gap

Cannabinoid scope: 28 register names within the documented search scope; no newly established direct finding for the target cannabinoid–drug pair. This must not be equated with 28 clinically studied combinations.

Evidence status: Drug properties from regulatory product information; insufficient data for a direct cannabinoid–drug pair finding in the material assessed.

Mechanism / drug context: Beta-2 agonism; bronchodilation and possible cardiovascular effects.

Type of supporting material: Targeted product-information review and documented individual literature screening; no newly verified direct cannabinoid–drug pair study.

Clinical interpretation: The clinical relevance of a specific cannabinoid combination has not been determined. Drug context may warrant individual professional review, but neither a blanket warning level nor an assurance of safety.

Context: Historical bronchodilator comparisons are not combined-exposure experiments.

Drug context and gaps in search results are not measured interactions. The source role below describes which statement the source actually supports.

Source role [VE_LABEL_D0335]: Medicine information: properties of the active substance

Statement supported: Beta-2 agonism; bronchodilation and possible cardiovascular effects. Product information: drug context, not evidence for a specific cannabinoid pair or proof of safety.

Source: ALBUTEROL SULFATE SOLUTION [LUOXIN AUROVITAS PHARMA (CHENGDU) CO., LTD.] [VE_LABEL_D0335]

Source role [VE_MED_797044]: Screened search result: no established pair evidence

Statement supported: THC, salbutamol and placebo as separate comparator treatments; no combined exposure.

Source: Bronchodilator effect of delta1-tetrahydrocannabinol administered by aerosol of asthmatic patients. [VE_MED_797044]

Source role [VE_MED_1124532]: Screened search result: no established pair evidence

Statement supported: Oral THC and salbutamol as comparator treatments; no investigated effect of the pair.

Source: A trial of oral delta-1-(trans)-tetrahydrocannabinol in reversible airways obstruction. [VE_MED_1124532]

Source role [VE_MED_35509440]: Screened search result: no established pair evidence

Statement supported: Cohort association of long-term cannabis use and airway function before/after a bronchodilator; not a controlled chemically defined THC–salbutamol interaction experiment.

Source: Lifetime cannabis exposure and small airway function in a population-based cohort study. [VE_MED_35509440]

Source role [C_PROTOCOL_D0335]: Documented search result

Statement supported: Documented title/abstract search scope for the active substance. The link displays the reproducible search query, not a study or proof that no interaction exists. Search date: 23 October 2026. Further search runs are documented in the research dataset.

Source: Reproducible literature search strategy: Salbutamol [C_PROTOCOL_D0335]

Scope of review: Individual research with documented title/abstract screening and targeted review of original sections. This is not exhaustive evidence that interactions are absent.

Unresolved source question: The existing individual review, label review and literature screening were read in full; targeted original PK/interaction passages were checked again, but not all product information and search results were newly reviewed in full text. Search findings are limited to the documented V5 search runs. The linked excluded search result was rechecked using its archived abstract or correction metadata record; this does not imply complete new access to the full text.

Separately recorded findings

No separately substantiated finding for this drug–cannabinoid pair is recorded within the documented scope of review. This does not prove that no such study exists anywhere or that the combination is safe.

References and access status

[VE_LABEL_D0335] ALBUTEROL SULFATE SOLUTION [LUOXIN AUROVITAS PHARMA (CHENGDU) CO., LTD.]

Original source / bibliographic reference

Authors: Respective marketing authorisation holder; regulatory product information

Year: 2026

Source type: Product information / SmPC / US Prescribing Information

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

[VE_MED_797044] Bronchodilator effect of delta1-tetrahydrocannabinol administered by aerosol of asthmatic patients.

Original source / bibliographic reference

Authors: Williams SJ, Hartley JP, Graham JD.

Year: 1976

Source type: Comparative Study; Clinical Trial; research-article; Randomized Controlled Trial; Journal Article

DOI: 10.1136/thx.31.6.720

PMID: 797044

Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.

Bibliographic attribution or source identity cross-checked.

PubMed – bibliographic reference / abstract

PubMed Central – full-text access according to the literature database – Archive attribution confirmed by Europe PMC metadata. Direct retrieval was not fully verified here; access may require a browser check.

Europe PMC – full-text access according to the literature database – Listed as freely available HTML full text in the official Europe PMC metadata. Direct retrieval was not fully verified here.

[VE_MED_1124532] A trial of oral delta-1-(trans)-tetrahydrocannabinol in reversible airways obstruction.

Original source / bibliographic reference

Authors: Davies BH, Radcliffe S, Seaton A, Graham JD.

Year: 1975

Source type: Controlled Clinical Trial; Comparative Study; Clinical Trial; research-article; Journal Article

DOI: 10.1136/thx.30.1.80

PMID: 1124532

Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.

Bibliographic attribution or source identity cross-checked.

PubMed – bibliographic reference / abstract

PubMed Central – full-text access according to the literature database – Archive attribution confirmed by Europe PMC metadata. Direct retrieval was not fully verified here; access may require a browser check.

Europe PMC – full-text access according to the literature database – Listed as freely available HTML full text in the official Europe PMC metadata. Direct retrieval was not fully verified here.

[VE_MED_35509440] Lifetime cannabis exposure and small airway function in a population-based cohort study.

Original source / bibliographic reference

Authors: Tan HS, McAnally HM, Dummer J, Hancox RJ.

Year: 2022

Source type: research-article; Journal Article

DOI: 10.1183/23120541.00688-2021

PMID: 35509440

Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.

Bibliographic attribution or source identity cross-checked.

PubMed – bibliographic reference / abstract

PubMed Central – full-text access according to the literature database – Archive attribution confirmed by Europe PMC metadata. Direct retrieval was not fully verified here; access may require a browser check.

Europe PMC – full-text access according to the literature database – Listed as freely available HTML full text in the official Europe PMC metadata. Direct retrieval was not fully verified here.

[C_PROTOCOL_D0335] Reproducible literature search strategy: Salbutamol

Original source / bibliographic reference

Authors: Europe PMC; documented search run

Year: 2026

Source type: Search strategy / screening protocol – not an individual study

Source access – 23 October 2026: Research protocol with machine-readable search results – not an individual study.

Research as of 23 October 2026. Not all original full texts could be reviewed in full. Source accessibility and the strength of scientific evidence must be assessed separately. An accessible link does not establish medical approval; a bibliographic record with an abstract does not replace the original full text.

Drug search and explanation of the evidence · Guide: cannabinoids and medicines · Author and responsibility