Paroxetine

For an informed discussion with your doctor or pharmacist. This information collection is not a clinically validated interaction checker. Missing data do not establish safety. Do not change or stop prescribed medicines on the basis of this information. The findings apply to the specific conditions studied; laboratory and animal studies cannot be directly extrapolated to humans.

Active substance: Paroxetine

Examples of brand names: Seroxat [DE]

ATC code: N06AB05

Main use (for orientation): Depression; anxiety

Documented research summary

A severe hypotension case involved anaesthetics, cannabis, amphetamines and paroxetine at the same time; the paediatric reassessment rates causality for the pair as doubtful. Another intoxication case involved cannabis and at least five medicines. Neither establishes isolated paroxetine–cannabinoid pharmacokinetics. The 2004 panic-disorder cohort showed a similar response to paroxetine following cannabis-associated onset of illness, but did not reliably examine continued, defined co-exposure. Comparator arms and radiolabelled paroxetine as a SERT marker are not therapeutic drug–drug interactions.

Uncertainties and limitations

No measured cannabinoid-related increase in paroxetine concentrations identified.

PMC11668912 contains shifted reference numbers; the original title and DOI of the hypotension case were checked separately. DIPS=1 indicates uncertain causality, not an established mechanism.

No class-specific evidence of safety for rare cannabinoids.

Separately recorded findings

2 separately recorded findings. Each statement applies to its documented study context.

Cannabis; composition not quantified – insufficient data

Finding ID: B0423

Type of result: Multiple-substance context, no isolatable drug–drug interaction

Observation: Confusion, hallucinations and sinus tachycardia after cannabis and a powder containing several prescription medicines.

Mechanism: Combined exposure; the mechanism of an individual pair cannot be determined

Study type: Multiple-substance intoxication case

Context studied: 16-year-old female patient; analysis identified several antidepressants and trihexyphenidyl in the powder.

Clinical interpretation: Interpret within the stated study context; no independent dosage or treatment recommendation.

Limitations and uncertainties: No isolated pair finding; individual quantities unknown and extensive exposure to multiple substances. Listed as safety context, not as an established cannabinoid interaction.

Original sources for this finding: Psychoactive cocktail consumption on Reunion Island: a case report. [BMED39953779]

Cannabis/marijuana; composition unknown – insufficient data

Finding ID: B0425

Type of result: Uncertain case reassessed in a secondary source

Observation: Severe hypotension was described in a surgical setting; a later structured case assessment rated interaction causality as doubtful (DIPS=1).

Mechanism: Multiple exposures including anaesthetics and amphetamines

Study type: Anaesthesiology case report, with details obtained through a secondary review

Context studied: Paediatric case involving paroxetine, cannabis, amphetamines and perioperative medicines.

Clinical interpretation: Interpret within the stated study context; no independent dosage or treatment recommendation.

Limitations and uncertainties: Original abstract/full text unavailable; details explicitly obtained from Chapin 2025, not independently extracted from the original. Reference numbers in the secondary source are inconsistent; original title/DOI checked. No established pharmacokinetics for the pair.

Original sources for this finding: Pharmacologic chaos: severe hypotension from interactions of anesthetics, marijuana, amphetamines, and paroxetine. [RMED30586660]; Part 1: Evaluation of Pediatric Cannabis-Drug Interaction Reports. [BMED39719830]

References and access status

[RLABEL_D0094] PAXIL CR (PAROXETINE HYDROCHLORIDE) TABLET, FILM COATED, EXTENDED RELEASE [APOTEX CORP]

Original source / bibliographic reference

Authors: Regulatory product information; respective marketing authorisation holder

Year: 2026

Source type: Product information / SmPC / US Prescribing Information

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

[BMED39953779] Psychoactive cocktail consumption on Reunion Island: a case report.

Original source / bibliographic reference

Authors: Guyon J, Maillot A, Bastard S, Weisse F, Daveluy A, Mété D.

Year: 2025

Source type: Publication; title and abstract reviewed

DOI: 10.1093/jat/bkaf009

PMID: 39953779

Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.

Bibliographic attribution or source identity cross-checked.

PubMed – bibliographic reference / abstract

DOI – publisher access (access restrictions may apply)

[BMED39719830] Part 1: Evaluation of Pediatric Cannabis-Drug Interaction Reports.

Original source / bibliographic reference

Authors: Chapin MR, Kane-Gill SL, Li X, Abanyie K, Taneja SB, Egbert S, Paine MF, Boyce RD.

Year: 2025

Source type: Secondary case review and FAERS analysis

DOI: 10.1002/prp2.70046

PMID: 39719830

Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.

Bibliographic attribution or source identity cross-checked.

PubMed – bibliographic reference / abstract

PubMed Central – archived text

DOI – publisher access (access restrictions may apply)

[RMED30586660] Pharmacologic chaos: severe hypotension from interactions of anesthetics, marijuana, amphetamines, and paroxetine.

Original source / bibliographic reference

Authors: Cossu AE, Latham LB, Hardacker DM, Jea AH.

Year: 2019

Source type: Original publication; see finding for study type

DOI: 10.1016/j.jclinane.2018.12.040

PMID: 30586660

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

PubMed – bibliographic reference / abstract

Research as of 23 October 2026. Not all original full texts could be reviewed in full. Source accessibility and the strength of scientific evidence must be assessed separately. An accessible link does not establish medical approval; a bibliographic record with an abstract does not replace the original full text.

Drug search and explanation of the evidence · Guide: cannabinoids and medicines · Author and responsibility