Naproxen

For an informed discussion with your doctor or pharmacist. This information collection is not a clinically validated interaction checker. Missing data do not establish safety. Do not change or stop prescribed medicines on the basis of this information. The findings apply to the specific conditions studied; laboratory and animal studies cannot be directly extrapolated to humans.

Active substance: Naproxen

Examples of brand names: Dolormin für Frauen [DE]

ATC code: M01AE02

Main use (for orientation): Pain; inflammation

Documented research summary

A cannabis extract reduced naproxen-induced gastric injury in a rat model; composition and clinical transferability remain unclear. No clinical naproxen–cannabinoid interaction identified; no assurance of safety for rare cannabinoids.

Uncertainties and limitations

Does not establish safety for less-studied cannabinoids or untested formulations/doses.

Do not infer clinical dosage from preclinical effects or enzyme hypotheses.

Separately recorded findings

1 separately recorded finding. Each statement applies to its documented study context.

Cannabis extract MFF, individual components not resolved – laboratory and animal studies

Finding ID: B0363

Type of result: Preclinical

Observation: Oral extract reduced naproxen-induced gastric injury in rats; a CB1 antagonist abolished the effect.

Mechanism: Preclinical CB1-dependent gastroprotective effect

Study type: Animal experiment

Context studied: Extract, oral versus systemic administration; abstract.

Clinical interpretation: Not clinically validated

Limitations and uncertainties: No dosing/safety statement for humans; not attributable to isolated CBD, THC or other individual cannabinoids.

Original sources for this finding: Pro-resolution, protective and anti-nociceptive effects of a cannabis extract in the rat gastrointestinal tract. [C_PR_23756391]

References and access status

[C_LABEL_D0165] NAPROXEN (NAPROXEN SODIUM) TABLET [GRANULES INDIA LTD]

Original source / bibliographic reference

Authors: GRANULES INDIA LTD

Year: 2026

Source type: US Structured Product Label

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

[C_PR_23756391] Pro-resolution, protective and anti-nociceptive effects of a cannabis extract in the rat gastrointestinal tract.

Original source / bibliographic reference

Authors: Wallace JL, Flannigan KL, McKnight W, Wang L, Ferraz JG, Tuitt D.

Year: 2013

Source type: Primary source, abstract read

PMID: 23756391

Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.

Bibliographic attribution or source identity cross-checked.

Unresolved access questions / further review: An animal experiment remains an animal experiment. Direct PubMed access shows an access check.

Journal – freely accessible original full text

Research as of 23 October 2026. Not all original full texts could be reviewed in full. Source accessibility and the strength of scientific evidence must be assessed separately. An accessible link does not establish medical approval; a bibliographic record with an abstract does not replace the original full text.

Drug search and explanation of the evidence · Guide: cannabinoids and medicines · Author and responsibility