Metoprolol

For an informed discussion with your doctor or pharmacist. This information collection is not a clinically validated interaction checker. Missing data do not establish safety. Do not change or stop prescribed medicines on the basis of this information. The findings apply to the specific conditions studied; laboratory and animal studies cannot be directly extrapolated to humans.

Active substance: Metoprolol

Examples of brand names: Beloc [DE]

ATC code: C07AB02

Main use (for orientation): Hypertension; cardiac conditions

Documented research summary

An absorption cocktail in rats contains metoprolol, THC, ibuprofen and CBD to investigate differing absorption kinetics between lipid vehicles; not a clinical metoprolol–cannabinoid drug–drug interaction or isolated evidence of enzyme inhibition.

Uncertainties and limitations

Metoprolol succinate extended-release tablet. Literature cocktail is an animal formulation, not a patient combination.

Shared enzymes must not be equated with clinical evidence of an interaction; CBD/THC findings cannot be extrapolated to other cannabinoids.

Separately recorded findings

2 separately recorded findings. Each statement applies to its documented study context.

CBD – laboratory and animal studies

Finding ID: B0264

Type of result: Preclinical

Observation: Metoprolol left the stomach earlier than the lipophilic cannabinoids in the oil cocktail.

Mechanism: Absorption-probe substance in the rat cocktail, formulation effect

Study type: Rat absorption/formulation study

Context studied: Metoprolol, ibuprofen, THC and CBD together; sesame oil versus a self-nanoemulsifying system.

Clinical interpretation: Laboratory measurement only, not a drug-interaction prediction

Limitations and uncertainties: Metoprolol as an absorption probe; not isolated cannabinoid inhibition of CYP2D6 or a clinical metoprolol-exposure prediction.

Original sources for this finding: Using the Absorption Cocktail Approach to Assess Differential Absorption Kinetics of Cannabidiol Administered in Lipid-Based Vehicles in Rats. [BMED32352800]

THC – laboratory and animal studies

Finding ID: B0265

Type of result: Preclinical

Observation: Metoprolol left the stomach earlier than the lipophilic cannabinoids in the oil cocktail.

Mechanism: Absorption-probe substance in the rat cocktail, formulation effect

Study type: Rat absorption/formulation study

Context studied: Metoprolol, ibuprofen, THC and CBD together; sesame oil versus a self-nanoemulsifying system.

Clinical interpretation: Laboratory measurement only, not a drug-interaction prediction

Limitations and uncertainties: Metoprolol as an absorption probe; not isolated cannabinoid inhibition of CYP2D6 or a clinical metoprolol-exposure prediction.

Original sources for this finding: Using the Absorption Cocktail Approach to Assess Differential Absorption Kinetics of Cannabidiol Administered in Lipid-Based Vehicles in Rats. [BMED32352800]

References and access status

[V2_LABEL_D0192] METOPROLOL SUCCINATE (METOPROLOL SUCCINATE ER TABLETS) TABLET, FILM COATED, EXTENDED RELEASE [ASCEND LABORATORIES, LLC]

Original source / bibliographic reference

Authors: Ascend Laboratories, LLC

Year: 2026

Source type: Official US SPL / DailyMed

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

[BMED32352800] Using the Absorption Cocktail Approach to Assess Differential Absorption Kinetics of Cannabidiol Administered in Lipid-Based Vehicles in Rats.

Original source / bibliographic reference

Authors: Izgelov D, Regev A, Domb AJ, Hoffman A.

Year: 2020

Source type: Publication; title and abstract reviewed

DOI: 10.1021/acs.molpharmaceut.0c00141

PMID: 32352800

Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.

Bibliographic attribution or source identity cross-checked.

PubMed – bibliographic reference / abstract

DOI – publisher access (access restrictions may apply)

Research as of 23 October 2026. Not all original full texts could be reviewed in full. Source accessibility and the strength of scientific evidence must be assessed separately. An accessible link does not establish medical approval; a bibliographic record with an abstract does not replace the original full text.

Drug search and explanation of the evidence · Guide: cannabinoids and medicines · Author and responsibility