Memantine

For an informed discussion with your doctor or pharmacist. This information collection is not a clinically validated interaction checker. Missing data do not establish safety. Do not change or stop prescribed medicines on the basis of this information. The findings apply to the specific conditions studied; laboratory and animal studies cannot be directly extrapolated to humans.

Active substance: Memantine

Examples of brand names: Ebixa [EU/DE]

ATC code: N06DX01

Main use (for orientation): Alzheimer's dementia

Documented research summary

THC/memantine rat study 31696510 reports a combined antitremor effect but carries an Expression of Concern, 37271499. Document as a preclinical report with an integrity limitation, not reliable clinical benefit. The cannabis-withdrawal catatonia case involving memantine is treatment context, not a pair interaction.

Uncertainties and limitations

Documented individual title/abstract review with selected relevant full texts; not an exhaustive worldwide systematic review and no independent human professional approval. Missing data do not establish safety. All 28 cannabinoids define the search scope, not 28 clinically studied pairs per active substance.

Separately recorded findings

1 separately recorded finding. Each statement applies to its documented study context.

THC – laboratory and animal studies

Finding ID: B0480

Type of result: Context-specific finding

Observation: The original paper reports an antitremor combination effect of memantine and THC.

Mechanism: NMDA/cannabinoid-related modulation in a tremor model.

Study type: Animal experiment with a published integrity notice

Context studied: Rat experiment; the article has an Expression of Concern (2023).

Clinical interpretation: Integrity limited: Expression of Concern. Do not use as reliable clinical treatment evidence.

Limitations and uncertainties: Integrity warning: use the finding only with substantial limitations, not as established efficacy or a clinical recommendation. An Expression of Concern is not a formal retraction.

Original sources for this finding: Neuroanatomical correlates of the inhibition of tremulous jaw movements in rats by a combination of memantine and Δ9 -tetrahydrocannabinol. [VF_P_31696510]; Expression of Concern: Neuroanatomical correlates of the inhibition of tremulous jaw movements in rats by a combination of memantine and Δ9 -tetrahydrocannabinol. [VF_P_37271499]

References and access status

[VF_L_D0416] MEMANTINE (MEMANTINE HYDROCHLORIDE) SOLUTION [APOTEX CORP.]

Original source / bibliographic reference

Authors: Marketing authorisation holder; official product information via DailyMed

Year: 2026

Source type: Official medicine information; relevant identity, PK, PD and DDI sections read individually

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

[VF_P_31696510] Neuroanatomical correlates of the inhibition of tremulous jaw movements in rats by a combination of memantine and Δ9 -tetrahydrocannabinol.

Original source / bibliographic reference

Authors: Ionov ID, Pushinskaya II, Frenkel DD, Gorev NP, Shpilevaya LA.

Year: 2020

Source type: Scientific publication; precise study type and suitability described in the finding or individual review

DOI: 10.1111/bph.14914

PMID: 31696510

Source access – 23 October 2026: Direct retrieval could not be fully verified; availability remains unresolved.

Bibliographic attribution or source identity cross-checked.

DOI – publisher access (access restrictions may apply)

PubMed Central – full-text access according to the literature database – Archive attribution confirmed by Europe PMC metadata. Direct retrieval was not fully verified here; access may require a browser check.

Europe PMC – full-text access according to the literature database – Listed as freely available HTML full text in the official Europe PMC metadata. Direct retrieval was not fully verified here.

[VF_P_37271499] Expression of Concern: Neuroanatomical correlates of the inhibition of tremulous jaw movements in rats by a combination of memantine and Δ9 -tetrahydrocannabinol.

Original source / bibliographic reference

Authors: No authors named in the PubMed record

Year: 2023

Source type: Expression of Concern; publication-integrity notice

DOI: 10.1111/bph.16150

PMID: 37271499

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

DOI – publisher access (access restrictions may apply)

Research as of 23 October 2026. Not all original full texts could be reviewed in full. Source accessibility and the strength of scientific evidence must be assessed separately. An accessible link does not establish medical approval; a bibliographic record with an abstract does not replace the original full text.

Drug search and explanation of the evidence · Guide: cannabinoids and medicines · Author and responsibility