Maprotiline

For an informed discussion with your doctor or pharmacist. This information collection is not a clinically validated interaction checker. Missing data do not establish safety. Do not change or stop prescribed medicines on the basis of this information. The findings apply to the specific conditions studied; laboratory and animal studies cannot be directly extrapolated to humans.

Active substance: Maprotiline

Examples of brand names: Ludiomil [DE; historical example]

ATC code: N06AA21

Main use (for orientation): Depression

Documented research summary

1975 animal study: maprotiline suppressed THC-induced muricidal behaviour. No conclusion about the safety/pharmacokinetics of co-administration in humans; older full-text version inaccessible.

Uncertainties and limitations

Does not establish safety for less-studied cannabinoids or untested formulations/doses.

Do not infer clinical dosage from preclinical effects or enzyme hypotheses.

Separately recorded findings

1 separately recorded finding. Each statement applies to its documented study context.

THC – laboratory and animal studies

Finding ID: B0328

Type of result: Preclinical

Observation: Suppression of THC-induced muricidal behaviour.

Mechanism: Behavioural pharmacology in a rat model.

Study type: Animal experiment; abstract

Context studied: 1975; no clinical dosing inference.

Clinical interpretation: Clinical significance undetermined

Limitations and uncertainties: One specific animal behavioural endpoint, not a general antipsychotic protective effect; full text inaccessible.

Original sources for this finding: [Behavior pharmacology of maprotiline, a new antidepressant]. [C_PR_1240830]

References and access status

[C_LABEL_D0104] Maprotilin-CT 50/75 mg Filmtabletten, Fachinformation

Original source / bibliographic reference

Authors: ratiopharm/manufacturer

Year: 2014

Source type: Historical German product information

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

[C_PR_1240830] [Behavior pharmacology of maprotiline, a new antidepressant].

Original source / bibliographic reference

Authors: Ueki S, Fujiwara M, Inoue K, Kataoka Y, Ibii N.

Year: 1975

Source type: Primary source, abstract read

DOI: 10.1254/fpj.71.789

PMID: 1240830

Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.

Bibliographic attribution or source identity cross-checked.

DOI – publisher access (access restrictions may apply)

Research as of 23 October 2026. Not all original full texts could be reviewed in full. Source accessibility and the strength of scientific evidence must be assessed separately. An accessible link does not establish medical approval; a bibliographic record with an abstract does not replace the original full text.

Drug search and explanation of the evidence · Guide: cannabinoids and medicines · Author and responsibility