Isoniazid

For an informed discussion with your doctor or pharmacist. This information collection is not a clinically validated interaction checker. Missing data do not establish safety. Do not change or stop prescribed medicines on the basis of this information. The findings apply to the specific conditions studied; laboratory and animal studies cannot be directly extrapolated to humans.

Active substance: Isoniazid

Examples of brand names: Isozid [DE]

ATC code: J04AC01

Main use (for orientation): Tuberculosis

Documented research summary

No clinically investigated interaction within the reviewed material. The historical rat cGMP model with THC is purely preclinical and should not be equated with human liver/neurotoxicity risk.

Uncertainties and limitations

Isoenzyme/transporter attribution incomplete in the label read; no invented additions.

Shared enzymes must not be equated with clinical evidence of an interaction; CBD/THC findings cannot be extrapolated to other cannabinoids.

Separately recorded findings

1 separately recorded finding. Each statement applies to its documented study context.

Δ9-THC – laboratory and animal studies

Finding ID: B0172

Type of result: Animal experiment

Observation: In historical work, THC was less active than levonantradol in a rat model.

Mechanism: Experimental alteration of isoniazid-induced elevation of cerebellar cGMP

Study type: Pharmacodynamic laboratory comparison

Context studied: The abstract reports relative activity, not a therapeutic isoniazid–cannabis combination in humans.

Clinical interpretation: No prediction of a clinical drug interaction.

Limitations and uncertainties: Assessment of doses/details requires full text; no practical risk rating.

Original sources for this finding: GABA-like actions of levonantradol. [BMED6271832]

References and access status

[V2_LABEL_D0305] ISONIAZID TABLET [REMEDYREPACK INC.]

Original source / bibliographic reference

Authors: REMEDYREPACK INC.

Year: 2026

Source type: Official US SPL / DailyMed

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

[BMED6271832] GABA-like actions of levonantradol.

Original source / bibliographic reference

Authors: Leader JP, Koe BK, Weissman A.

Year: 1981

Source type: Publication; title and abstract reviewed

DOI: 10.1002/j.1552-4604.1981.tb02604.x

PMID: 6271832

Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.

Bibliographic attribution or source identity cross-checked.

PubMed – bibliographic reference / abstract

DOI – publisher access (access restrictions may apply)

Research as of 23 October 2026. Not all original full texts could be reviewed in full. Source accessibility and the strength of scientific evidence must be assessed separately. An accessible link does not establish medical approval; a bibliographic record with an abstract does not replace the original full text.

Drug search and explanation of the evidence · Guide: cannabinoids and medicines · Author and responsibility