Ibuprofen

For an informed discussion with your doctor or pharmacist. This information collection is not a clinically validated interaction checker. Missing data do not establish safety. Do not change or stop prescribed medicines on the basis of this information. The findings apply to the specific conditions studied; laboratory and animal studies cannot be directly extrapolated to humans.

Active substance: Ibuprofen

Examples of brand names: Nurofen [DE]

ATC code: M01AE01

Main use (for orientation): Pain; inflammation

Documented research summary

A direct human RCT found no additional analgesic benefit of dronabinol added to ibuprofen in a specific setting. Cell models show context-dependent effects of CBD or a CBD/CBG/THCV mixture; no clinically quantified ibuprofen pharmacokinetic interaction can be inferred.

Uncertainties and limitations

Does not establish safety for less-studied cannabinoids or untested formulations/doses.

Do not infer clinical dosage from preclinical effects or enzyme hypotheses.

Separately recorded findings

3 separately recorded findings. Each statement applies to its documented study context.

THC – clinically investigated

Finding ID: B0377

Type of result: Clinical combination; no additional benefit in the endpoint investigated

Observation: Dronabinol added to ibuprofen did not reduce maximum pain during medication abortion: median 7 in both groups, p=0.82.

Mechanism: Pharmacodynamic additional analgesia assessed.

Study type: Human RCT, n=70; abstract

Context studied: Single dronabinol 5 mg dose or placebo; both groups received ibuprofen 800 mg.

Clinical interpretation: Limited to the model investigated

Limitations and uncertainties: No ibuprofen pharmacokinetics measured; no safety evidence for other cannabinoids, doses or long-term use.

Original sources for this finding: Cannabinoids for Pain Control During Medical Abortion: A Randomized Controlled Trial. [C_PR_32459420]

CBD + CBG + THCV (mixture) – laboratory and animal studies

Finding ID: B0378

Type of result: Preclinical evidence

Observation: FCBD:std and ibuprofen synergistically reduced IL-8 in KG1/A549 cells at certain concentrations. IL-8 reduction in 3D co-culture, but no consistent IL-6 reduction.

Mechanism: Experimental inflammatory markers and Bliss synergy.

Study type: In-vitro mono/co-culture and 3D model

Context studied: For example, ibuprofen 400 µg/ml and FCBD:std 25 µg/ml in co-culture; highly concentrated mixture.

Clinical interpretation: Limited to the model investigated

Limitations and uncertainties: Do not attribute the mixture effect to individual cannabinoids; tumour cell lines and very high concentrations, not a clinical interaction or treatment recommendation.

Original sources for this finding: Phytocannabinoids Act Synergistically with Non-Steroidal Anti-Inflammatory Drugs Reducing Inflammation in 2D and 3D In Vitro Models. [C_PR_36559009]

CBD – laboratory and animal studies

Finding ID: B0379

Type of result: Preclinical evidence

Observation: CBD plus ibuprofen reduced A431 cell viability and NF-κB activity; do not infer established pharmacological synergy over individual substances from this paper.

Mechanism: Experimental cytotoxicity/apoptosis and NF-κB.

Study type: In-vitro cell study

Context studied: A431 vulvar carcinoma, HaCaT and EA.hy926; 24-hour exposure, equimolar combinations.

Clinical interpretation: Limited to the model investigated

Limitations and uncertainties: Non-malignant cells also affected. Authors call for additional synergy/additivity assessment. No cancer-treatment recommendation.

Original sources for this finding: Cannabidiol and Its Combinations with Nonsteroidal Anti-Inflammatory Drugs Induce Apoptosis and Inhibit Activation of NF-κB Signaling in Vulvar Squamous Cell Carcinoma. [C_PR_36557911]

References and access status

[C_LABEL_D0163_UK] Ibuprofen 400 mg film-coated tablets, Aurobindo/Milpharm, UK SmPC PL 16363/0526

Original source / bibliographic reference

Authors: Aurobindo Pharma - Milpharm Ltd.

Year: 2026

Source type: Official UK SmPC

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

[C_PR_32459420] Cannabinoids for Pain Control During Medical Abortion: A Randomized Controlled Trial.

Original source / bibliographic reference

Authors: Colwill AC, Alton K, Bednarek PH, Bayer LL, Jensen JT, Garg B, Beardsworth K, Edelman A.

Year: 2020

Source type: Primary source, abstract read

DOI: 10.1097/aog.0000000000003850

PMID: 32459420

Source access – 23 October 2026: Direct retrieval could not be fully verified; availability remains unresolved.

Bibliographic attribution or source identity cross-checked.

DOI – publisher access (access restrictions may apply)

[C_PR_36559009] Phytocannabinoids Act Synergistically with Non-Steroidal Anti-Inflammatory Drugs Reducing Inflammation in 2D and 3D In Vitro Models.

Original source / bibliographic reference

Authors: Vinayaka AC, Shalev N, Anil SM, Tiwari S, Kumar N, Belausov E, Mani KA, Mechrez G, Koltai H.

Year: 2022

Source type: Primary source, relevant full-text sections read

DOI: 10.3390/ph15121559

PMID: 36559009

Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.

Bibliographic attribution or source identity cross-checked.

PubMed – bibliographic reference / abstract

PubMed Central – archived text

DOI – publisher access (access restrictions may apply)

[C_PR_36557911] Cannabidiol and Its Combinations with Nonsteroidal Anti-Inflammatory Drugs Induce Apoptosis and Inhibit Activation of NF-κB Signaling in Vulvar Squamous Cell Carcinoma.

Original source / bibliographic reference

Authors: Krajka-Kuźniak V, Papierska K, Narożna M, Jelińska A, Majchrzak-Celińska A.

Year: 2022

Source type: Primary source, relevant full-text sections read

DOI: 10.3390/molecules27248779

PMID: 36557911

Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.

Bibliographic attribution or source identity cross-checked.

PubMed – bibliographic reference / abstract

PubMed Central – archived text

DOI – publisher access (access restrictions may apply)

[C_PR_42771648] Evaluating the impact of cannabinoid extracts on chronic pain and quality of life in endometriosis patients - a pilot study.

Original source / bibliographic reference

Authors: Kratz JW, Velho RV, Bock S, Sehouli J, Mechsner S.

Year: 2026

Source type: Primary source, relevant full-text sections read

DOI: 10.1371/journal.pone.0356768

PMID: 42771648

Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.

Bibliographic attribution or source identity cross-checked.

PubMed – bibliographic reference / abstract

PubMed Central – archived text

DOI – publisher access (access restrictions may apply)

Research as of 23 October 2026. Not all original full texts could be reviewed in full. Source accessibility and the strength of scientific evidence must be assessed separately. An accessible link does not establish medical approval; a bibliographic record with an abstract does not replace the original full text.

Drug search and explanation of the evidence · Guide: cannabinoids and medicines · Author and responsibility