Hydrocortisone

For an informed discussion with your doctor or pharmacist. This information collection is not a clinically validated interaction checker. Missing data do not establish safety. Do not change or stop prescribed medicines on the basis of this information. The findings apply to the specific conditions studied; laboratory and animal studies cannot be directly extrapolated to humans.

Active substance: Hydrocortisone

Examples of brand names: Hydrocortison Hoechst [DE]

ATC code: H02AB09

Main use (for orientation): Adrenal insufficiency; inflammation

Documented research summary

Official registry results for 13 women show a THC AUC ratio of 0.98 (90% confidence interval 0.76–1.3) after hydrocortisone pretreatment. AUC describes drug exposure in blood over 24 hours. THC and 11-OH-THC intervals are not fully within the specified equivalence limits; therefore neither absence of interaction nor a clinically important interaction is proven. A separately recorded non-peer-reviewed preprint abstract reports changes in individual carboxy-metabolite parameters. Historical rat and tilapia experiments allow no direct conclusions for humans. Not general safety evidence.

Uncertainties and limitations

Preprint not peer reviewed; author names only as in registry metadata, no added first names.

Historical Delta1-THC name reflects older numbering; original structure not separately verified.

Registry results assessed; original preprint full text remains unresolved. Precise publication attribution and contradictory registry randomisation details remain unresolved.

Separately recorded findings

3 separately recorded findings. Each statement applies to its documented study context.

THC (dronabinol) – clinical signals

Finding ID: B0410

Type of result: Preliminary human findings from registry results and preprint abstract; absence of interaction not established

Observation: Official registry results for 13 women after hydrocortisone pretreatment show THC AUC ratio 0.98 (90% confidence interval 0.76–1.3) and 11-OH-THC AUC ratio 1.2 (90% confidence interval 0.79–1.7). AUC here describes drug exposure in blood over 24 hours; treatment was compared with the control day. These intervals are not fully within registry limits of 0.80–1.25, so equivalence is not established for these parameters. This is neither proof of a clinically important interaction nor evidence of no interaction. The separately recorded preprint abstract additionally reports changes in individual carboxy-metabolite parameters.

Mechanism: Influence of increased cortisol exposure on THC-metabolite disposition

Study type: Human pharmacokinetic registry results and non-peer-reviewed preprint abstract

Context studied: Healthy premenopausal women; registry NCT04374773 with 14 enrolled and 13 analysed in the hydrocortisone arm. Comparison before and after one week of oral hydrocortisone, each with oral dronabinol. Not a pregnancy study. The matching preprint abstract also names 13 women; its original full text and precise registry attribution not conclusively verified.

Clinical interpretation: Interpret within the stated study context; no independent dosage or treatment recommendation.

Limitations and uncertainties: Small selected group and short exposure. Effect sizes/confidence intervals checked in the official registry, not the still-unresolved preprint full text. Registry label EQUIVALENCE is not successful equivalence evidence. Randomisation details contradict one another within the registry; complete analysis methods and reasons for different analysis counts remain open. No general safety evidence or extrapolation to pregnancy/long-term therapy.

Original sources for this finding: Increased cortisol exposure alters 11-COOH-THC disposition without affecting THC pharmacokinetics in premenopausal, healthy women [RMEDPPR1206798]; Effects of Pregnancy-associated Hormones on THC Metabolism in Women (PrECEPT): veröffentlichte Registerergebnisse [RREG_NCT04374773]

THC; historical name Δ1-THC – laboratory and animal studies

Finding ID: B0411

Type of result: Animal model, context-dependent pharmacodynamics

Observation: Hydrocortisone restored duration of THC-induced blood-pressure reduction in adrenalectomised rats; THC bradycardia enhanced in sham animals.

Mechanism: Glucocorticoid-dependent cardiovascular effects

Study type: Anaesthetised rats, adrenalectomised or sham-operated

Context studied: THC 1 mg/kg intravenously; hydrocortisone 25 µg/kg intravenously 45 minutes earlier.

Clinical interpretation: Interpret within the stated study context; no independent dosage or treatment recommendation.

Limitations and uncertainties: Historical experiment; not human risk quantification. Older THC nomenclature; original structure not separately verified.

Original sources for this finding: The effects of adrenalectomy on the cardiovascular responses to delta 1-tetrahydrocannabinol in rats. [RMED668209]

CBD – laboratory and animal studies

Finding ID: B0412

Type of result: Preclinical stress-model context

Observation: CBD affected lysozyme activity during hydrocortisone stress; other stress biomarkers showed no significant improvement.

Mechanism: Stress biomarkers in a chronic hydrocortisone model

Study type: Nile tilapia aquaculture experiment

Context studied: Feeding for 4 weeks, CBD 0.001% of feed weight, hydrocortisone 0.01% of body weight.

Clinical interpretation: Interpret within the stated study context; no independent dosage or treatment recommendation.

Limitations and uncertainties: Fish, not human medicine; no drug-dosage or safety conclusion.

Original sources for this finding: Effects of CBD (Cannabidiol) on the physiology of Nile tilapia (Oreochromisn niloticus) as a chronic stress mitigating agent In-vivo. [RMED37713426]

References and access status

[RLABEL_D0037] SOLU-CORTEF (HYDROCORTISONE SODIUM SUCCINATE) INJECTION, POWDER, FOR SOLUTION [PHARMACIA & UPJOHN COMPANY LLC]

Original source / bibliographic reference

Authors: Regulatory product information; respective marketing authorisation holder

Year: 2026

Source type: Product information / SmPC / US Prescribing Information

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

[RMEDPPR1206798] Increased cortisol exposure alters 11-COOH-THC disposition without affecting THC pharmacokinetics in premenopausal, healthy women

Original source / bibliographic reference

Authors: K AA, K JA, B KR, Isoherranen N.

Year: 2026

Source type: Non-peer-reviewed human preprint; registry abstract assessed, original full text not verified

DOI: 10.22541/authorea.15003186/v1

Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.

Bibliographic attribution or source identity cross-checked.

Unresolved access questions / further review: The official preprint abstract assessed; original full text remains unverified. Additionally, official results of the matching research project NCT04374773 are available under a separate source. Confidence intervals can now be checked there, not in the manuscript. Matching study features suggest a relationship; direct publication reference and complete comparison remain unresolved. No equivalence or general safety evidence. Unusual segmentation of author names still comes from metadata and has not been confirmed in the manuscript. Non-peer-reviewed preprint, not a pregnancy study.

Europe PMC – bibliographic data and abstract (JSON; not full text) – Official bibliographic record successfully checked. The view is machine-readable and is not the original full text.

[RMED668209] The effects of adrenalectomy on the cardiovascular responses to delta 1-tetrahydrocannabinol in rats.

Original source / bibliographic reference

Authors: Li DM, Chung JP.

Year: 1978

Source type: Original publication; see finding for study type

DOI: 10.1111/j.1440-1681.1978.tb00673.x

PMID: 668209

Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.

Bibliographic attribution or source identity cross-checked.

PubMed – bibliographic reference / abstract

[RMED37713426] Effects of CBD (Cannabidiol) on the physiology of Nile tilapia (Oreochromisn niloticus) as a chronic stress mitigating agent In-vivo.

Original source / bibliographic reference

Authors: Mortuza A, Fahim N, Ahmed M, Mustafa A.

Year: 2023

Source type: Original publication; see finding for study type

DOI: 10.1371/journal.pone.0290835

PMID: 37713426

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

PubMed – bibliographic reference / abstract

[RREG_NCT04374773] Effects of Pregnancy-associated Hormones on THC Metabolism in Women (PrECEPT): veröffentlichte Registerergebnisse

Original source / bibliographic reference

Authors: University of Washington (sponsor); Nina Isoherranen (responsible investigator)

Year: 2026

Source type: Official results report submitted by the study investigator to the trial registry; not a peer-reviewed journal article

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

Unresolved access questions / further review: Results first published on 6 May 2026; official API export read on 23 October 2026. 14 enrolled, hydrocortisone analysis 13, oestradiol analysis 12. Registry report does not replace the unresolved Authorea full text. Contradictory registry randomisation details; absence of interaction not confirmed. Preprint attribution remains provisional; registry report and preprint must not count as two independent studies.

ClinicalTrials.gov – official results export (JSON) – Complete public registry export with protocol, participant flow and results tables; machine-readable, not article full text.

Research as of 23 October 2026. Not all original full texts could be reviewed in full. Source accessibility and the strength of scientific evidence must be assessed separately. An accessible link does not establish medical approval; a bibliographic record with an abstract does not replace the original full text.

Drug search and explanation of the evidence · Guide: cannabinoids and medicines · Author and responsibility