Furosemide

For an informed discussion with your doctor or pharmacist. This information collection is not a clinically validated interaction checker. Missing data do not establish safety. Do not change or stop prescribed medicines on the basis of this information. The findings apply to the specific conditions studied; laboratory and animal studies cannot be directly extrapolated to humans.

Active substance: Furosemide

Examples of brand names: Lasix [DE]

ATC code: C03CA01

Main use (for orientation): Oedema; heart failure

Documented research summary

Mice: furosemide diuresis unchanged following 7 days of THC pretreatment (2016). Limited negative pharmacodynamic finding. The CBD–ethanol/diuretic work and the 2013 diuresis study are comparisons, not clinical pair-specific drug–drug interactions.

Uncertainties and limitations

Missing data do not establish safety. Research is limited by the documented sources, search terms, languages and accessibility.

Separately recorded findings

1 separately recorded finding. Each statement applies to its documented study context.

THC – laboratory and animal studies

Finding ID: B0430

Type of result: Negative experimental finding

Observation: The diuretic response to furosemide remained unchanged after seven days of THC treatment, unlike the response to a kappa-opioid agonist.

Mechanism: Investigation of functional cross-tolerance in the diuretic response following repeated THC exposure.

Study type: Animal experiment (mouse)

Context studied: Mice received THC 10 mg/kg daily for 7 days; dose–response relationships were then investigated again.

Clinical interpretation: Clinical significance unresolved

Limitations and uncertainties: Abstract read; sequential animal experiment, no general statement on simultaneous treatment in humans or other endpoints.

Original sources for this finding: Tolerance to the Diuretic Effects of Cannabinoids and Cross-Tolerance to a κ-Opioid Agonist in THC-Treated Mice. [VD_MED_27231154]

References and access status

[VD_LABEL_D0227] FUROSEMIDE (FUROSEMIDE) TABLET [REMEDYREPACK INC.] – DailyMed SPL

Original source / bibliographic reference

Authors: Marketing authorisation holder / label provider according to the linked DailyMed product information

Year: 2026

Source type: Regulatory product information (US SPL)

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

[VD_MED_27231154] Tolerance to the Diuretic Effects of Cannabinoids and Cross-Tolerance to a κ-Opioid Agonist in THC-Treated Mice.

Original source / bibliographic reference

Authors: Chopda GR, Parge V, Thakur GA, Gatley SJ, Makriyannis A, Paronis CA.

Year: 2016

Source type: Research Support, Non-U.S. Gov't; research-article; Journal Article; Research Support, N.I.H., Extramural

DOI: 10.1124/jpet.116.232132

PMID: 27231154

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

PubMed – bibliographic reference / abstract

Research as of 23 October 2026. Not all original full texts could be reviewed in full. Source accessibility and the strength of scientific evidence must be assessed separately. An accessible link does not establish medical approval; a bibliographic record with an abstract does not replace the original full text.

Drug search and explanation of the evidence · Guide: cannabinoids and medicines · Author and responsibility