Dimenhydrinate

For an informed discussion with your doctor or pharmacist. This information collection is not a clinically validated interaction checker. Missing data do not establish safety. Do not change or stop prescribed medicines on the basis of this information. The findings apply to the specific conditions studied; laboratory and animal studies cannot be directly extrapolated to humans.

Active substance: Dimenhydrinate

Examples of brand names: Vomex A [DE]

ATC code: R06AA11

Main use (for orientation): Nausea; motion sickness

Documented research summary

PMID 38453220: long-term high-dose misuse, cannabis history and several possible causes; no causally established cannabinoid–dimenhydrinate interaction. Missing data do not establish safety.

Uncertainties and limitations

The 28 cannabinoid names in the register define the search scope, not 28 clinically studied pairs. Missing data do not establish safety.

No complete new systematic literature search and no independent medical or pharmaceutical professional approval. Note the dosage form and the country of authorisation of the product information.

Chewing-gum formulation assessed, not every Vomex formulation. Do not assume CYP-dependent prodrug activation.

Structured assessment

Category: Drug context

Cannabinoid scope: 28 register names within the documented search scope; no newly established direct finding for the target cannabinoid–drug pair. This must not be equated with 28 clinically studied combinations.

Evidence status: Drug properties from regulatory product information; insufficient data for a direct cannabinoid–drug pair finding in the material assessed.

Mechanism / drug context: Diphenhydramine–chlorotheophylline salt, centrally depressant/anticholinergic; extensive hepatic metabolism.

Type of supporting material: Targeted product-information review and documented individual literature screening; no newly verified direct cannabinoid–drug pair study.

Clinical interpretation: The clinical relevance of a specific cannabinoid combination has not been determined. Drug context may warrant individual professional review, but neither a blanket warning level nor an assurance of safety.

Context: Chewing-gum formulation assessed, not every Vomex formulation. Do not assume CYP-dependent prodrug activation.

Drug context and gaps in search results are not measured interactions. The source role below describes which statement the source actually supports.

Source role [BWEB08]: Medicine information: properties of the active substance

Statement supported: Diphenhydramine–chlorotheophylline salt, centrally depressant/anticholinergic; extensive hepatic metabolism. Product information: drug context, not evidence for a specific cannabinoid pair or proof of safety.

Source: Biodramina 20 mg chicles medicamentosos Ficha Técnica [BWEB08]

Source role [C_PRIM_38453220]: Screened search result: no established pair evidence

Statement supported: Abstract of a multifactorial single case: cannabis history and dimenhydrinate misuse, not a causally established cannabinoid pair finding.

Source: Chronic high-dose dimenhydrinate use contributing to early multifactorial cognitive impairment. [C_PRIM_38453220]

Source role [C_PROTOCOL_D0351]: Documented search result

Statement supported: Documented title/abstract search scope for the active substance. The link displays the reproducible search query, not a study or proof that no interaction exists. Search date: 22 October 2026. Further search runs are documented in the research dataset.

Source: Reproducible literature search strategy: Dimenhydrinat [C_PROTOCOL_D0351]

Scope of review: Individual research with documented title/abstract screening and targeted review of original sections. This is not exhaustive evidence that interactions are absent.

Unresolved source question: Existing individual review, label review and literature screening read in full; targeted original pharmacokinetic/interaction passages rechecked, not all prescribing information and search results newly assessed in full text. Search findings limited to documented V5 searches. PMID 38453220: search result/abstract and metadata reread; direct PMC full-text retrieval blocked. Case full text not newly assessed in full.

Separately recorded findings

No separately substantiated finding for this drug–cannabinoid pair is recorded within the documented scope of review. This does not prove that no such study exists anywhere or that the combination is safe.

References and access status

[BWEB08] Biodramina 20 mg chicles medicamentosos Ficha Técnica

Original source / bibliographic reference

Authors: Uriach Consumer Healthcare / AEMPS CIMA

Year: 2024

Source type: Regulatory product information / SmPC

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

[C_PRIM_38453220] Chronic high-dose dimenhydrinate use contributing to early multifactorial cognitive impairment.

Original source / bibliographic reference

Authors: Fabiano N, Dholakia S, Walker LAS, Smith AL.

Year: 2024

Source type: Single case report; abstract assessed, no causal cannabinoid pair evidence

DOI: 10.1136/bcr-2023-258493

PMID: 38453220

Source access – 23 October 2026: Direct retrieval could not be fully verified; availability remains unresolved.

Bibliographic attribution or source identity cross-checked.

DOI – publisher access (access restrictions may apply)

PubMed Central – full-text access according to the literature database – Archive attribution confirmed by Europe PMC metadata. Direct retrieval was not fully verified here; access may require a browser check.

Europe PMC – full-text access according to the literature database – Listed as freely available HTML full text in the official Europe PMC metadata. Direct retrieval was not fully verified here.

[C_PROTOCOL_D0351] Reproducible literature search strategy: Dimenhydrinat

Original source / bibliographic reference

Authors: Europe PMC; documented search run

Year: 2026

Source type: Search strategy / screening protocol – not an individual study

Source access – 23 October 2026: Research protocol with machine-readable search results – not an individual study.

Research as of 23 October 2026. Not all original full texts could be reviewed in full. Source accessibility and the strength of scientific evidence must be assessed separately. An accessible link does not establish medical approval; a bibliographic record with an abstract does not replace the original full text.

Drug search and explanation of the evidence · Guide: cannabinoids and medicines · Author and responsibility