Dexamfetamine

For an informed discussion with your doctor or pharmacist. This information collection is not a clinically validated interaction checker. Missing data do not establish safety. Do not change or stop prescribed medicines on the basis of this information. The findings apply to the specific conditions studied; laboratory and animal studies cannot be directly extrapolated to humans.

Active substance: Dexamfetamine

Examples of brand names: Attentin [DE]

ATC code: N06BA02

Main use (for orientation): ADHD

Documented research summary

Evans' controlled cannabis–dexamfetamine experiment in 1976 showed additive effects on heart rate and blood pressure; psychomotor effects in the second experiment were similar to those of cannabis alone. A cannabis preparation, not purified THC; no pharmacokinetic evidence.

Uncertainties and limitations

Small historical experiments; participant number not stated in the abstract. Documented individual title/abstract review with selected relevant full texts; not an exhaustive worldwide systematic review and no independent human professional approval. Missing data do not establish safety. All 28 cannabinoids define the search scope, not 28 clinically studied pairs per active substance.

Separately recorded findings

1 separately recorded finding. Each statement applies to its documented study context.

THC in smoked cannabis – clinically studied

Finding ID: B0487

Type of result: Context-specific finding

Observation: The combination had additive effects on heart rate and blood pressure; psychomotor effects were not uniformly increased.

Mechanism: Additive cardiovascular stimulation from dexamfetamine and cannabis.

Study type: Controlled human experiments, pharmacodynamics

Context studied: Dexamfetamine 10 mg/70 kg; in the main experiment, cannabis containing THC at 50 µg/kg; additional conditions within the same research programme.

Clinical interpretation: Human endpoint directly studied under narrowly defined study conditions; long-term safety and generalisability not established.

Limitations and uncertainties: Small historical short-term experiments; do not count the two publications as two independent populations. No evidence of long-term safety or an identical effect with every formulation.

Original sources for this finding: Effects of marihuana-dextroamphetamine combination. [VF_P_782773]; The combined effect of marihuana and dextroamphetamine. [VF_P_798521]

References and access status

[VF_L_D0428] DEXTROAMPHETAMINE SULFATE TABLET [AUROLIFE PHARMA, LLC]

Original source / bibliographic reference

Authors: Marketing authorisation holder; official product information via DailyMed

Year: 2026

Source type: Official medicine information; relevant identity, PK, PD and DDI sections read individually

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

[VF_P_782773] Effects of marihuana-dextroamphetamine combination.

Original source / bibliographic reference

Authors: Evans MA, Martz R, Rodda BE, Lemberger L, Forney RB.

Year: 1976

Source type: Scientific publication; precise study type and suitability described in the finding or individual review

DOI: 10.1002/cpt1976203350

PMID: 782773

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

DOI – publisher access (access restrictions may apply)

[VF_P_798521] The combined effect of marihuana and dextroamphetamine.

Original source / bibliographic reference

Authors: Forney R, Martz R, Lemberger L, Rodda B.

Year: 1976

Source type: Scientific publication; precise study type and suitability described in the finding or individual review

DOI: 10.1111/j.1749-6632.1976.tb27928.x

PMID: 798521

Source access – 23 October 2026: Direct retrieval could not be fully verified; availability remains unresolved.

Bibliographic attribution or source identity cross-checked.

DOI – publisher access (access restrictions may apply)

Research as of 23 October 2026. Not all original full texts could be reviewed in full. Source accessibility and the strength of scientific evidence must be assessed separately. An accessible link does not establish medical approval; a bibliographic record with an abstract does not replace the original full text.

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