Clonazepam

For an informed discussion with your doctor or pharmacist. This information collection is not a clinically validated interaction checker. Missing data do not establish safety. Do not change or stop prescribed medicines on the basis of this information. The findings apply to the specific conditions studied; laboratory and animal studies cannot be directly extrapolated to humans.

Active substance: Clonazepam

Examples of brand names: Rivotril [DE]

ATC code: N03AE01

Main use (for orientation): Epilepsy

Documented research summary

CL20 showed no significant association between CBD and concentrations. Preclinical Dravet-syndrome mice: CBD + clonazepam reduced seizure duration, not human evidence. A status epilepticus case involving polytherapy does not permit attribution to clonazepam.

Uncertainties and limitations

Urinary metabolite-ratio abstract without pair-specific numbers; full text unresolved. Not a general finding establishing safety.

Separately recorded findings

1 separately recorded finding. Each statement applies to its documented study context.

CBD – clinical signals

Finding ID: B0058

Type of result: No / minor effect under the conditions studied

Observation: No concentration signal; p=0.6367.

Mechanism: PK observation

Study type: Observational study: no signal detected

Context studied: n=45.

Clinical interpretation: Not ruled out

Limitations and uncertainties: Context / limitations of CL20; a lack of statistical significance does not establish equivalence.

Original sources for this finding: Final analysis of potential drug-drug interactions between highly purified cannabidiol and anti-seizure medications in an open-label expanded access program [CL20]

References and access status

[CA_L_D0072] KLONOPIN (CLONAZEPAM) TABLET [H2-PHARMA, LLC]

Original source / bibliographic reference

Authors: H2-Pharma, LLC

Year: 2025

Source type: Current published human-use SPL / product information

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

[CL20] Final analysis of potential drug-drug interactions between highly purified cannabidiol and anti-seizure medications in an open-label expanded access program

Original source / bibliographic reference

Authors: Gaston TE; Bebin EM; Cutter GR; Grayson L; Szaflarski JP

Year: 2023

Source type: Open-label longitudinal observational study

DOI: 10.1002/epi4.12815

PMID: 37593907

Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.

Bibliographic attribution or source identity cross-checked.

PubMed – bibliographic reference / abstract

DOI – publisher access (access restrictions may apply)

Europe PMC – full-text access according to the literature database – Listed as freely available HTML full text in the official Europe PMC metadata. Direct retrieval was not fully verified here.

[CA_P_34308420] Combined Antiseizure Efficacy of Cannabidiol and Clonazepam in a Conditional Mouse Model of Dravet Syndrome.

Original source / bibliographic reference

Authors: Chuang SH, Westenbroek RE, Stella N, Catterall WA.

Year: 2021

Source type: research-article; Journal Article

DOI: 10.33696/neurol.2.040

PMID: 34308420

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

DOI – publisher access (access restrictions may apply)

Research as of 23 October 2026. Not all original full texts could be reviewed in full. Source accessibility and the strength of scientific evidence must be assessed separately. An accessible link does not establish medical approval; a bibliographic record with an abstract does not replace the original full text.

Drug search and explanation of the evidence · Guide: cannabinoids and medicines · Author and responsibility