Bupropion

For an informed discussion with your doctor or pharmacist. This information collection is not a clinically validated interaction checker. Missing data do not establish safety. Do not change or stop prescribed medicines on the basis of this information. The findings apply to the specific conditions studied; laboratory and animal studies cannot be directly extrapolated to humans.

Active substance: Bupropion

Examples of brand names: Elontril [DE]; Zyban [DE]

ATC code: N06AX12

Main use (for orientation): Depression; smoking cessation

Documented research summary

FDA Epidiolex label CL02: CBD reduced bupropion AUC by 20% and Cmax by 19%, with hydroxybupropion unchanged. This contradicts a blanket claim that CBD increases every CYP substrate. A small withdrawal experiment showed worse mood with bupropion during cannabis withdrawal, with few effects during active smoking.

Uncertainties and limitations

The bupropion withdrawal effect is not identical to an acute pharmacokinetic interaction; the new urine-ratio paper without pair figures was not extrapolated.

Separately recorded findings

1 separately recorded finding. Each statement applies to its documented study context.

CBD – clinically studied

Finding ID: B0004

Type of result: Positive finding / indication

Observation: AUC −20%, Cmax −19%; hydroxybupropion unchanged.

Mechanism: CYP2B6; complex net effect

Study type: Human pharmacokinetics according to product information

Context studied: CBD 7.5 mg/kg twice daily; bupropion 150 mg; n not stated.

Clinical interpretation: Small in the regimen investigated

Limitations and uncertainties: Higher CBD exposure remains unresolved. EU prescribing information section 4.5 assesses the measured reduction as within the observed variability and not clinically significant. Do not infer general safety clearance.

Original sources for this finding: EPIDIOLEX (cannabidiol) oral solution – US Prescribing Information, revised 5/2026 [V5_US_LABEL_2026]; EPIDIOLEX (cannabidiol) oral solution – Prescribing Information, revised 6/2025 [CL02]

References and access status

[CA_L_D0112] BUPROPION HYDROCHLORIDE SR (BUPROPION HYDROCHLORIDE) TABLET, FILM COATED, EXTENDED RELEASE [REMEDYREPACK INC.]

Original source / bibliographic reference

Authors: REMEDYREPACK INC.

Year: 2026

Source type: Current published human-use SPL / product information

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

[CL02] EPIDIOLEX (cannabidiol) oral solution – Prescribing Information, revised 6/2025

Original source / bibliographic reference

Authors: FDA / Jazz Pharmaceuticals

Year: 2025

Source type: Regulatory product information

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

[CA_P_11401006] Bupropion SR worsens mood during marijuana withdrawal in humans.

Original source / bibliographic reference

Authors: Haney M, Ward AS, Comer SD, Hart CL, Foltin RW, Fischman MW.

Year: 2001

Source type: Clinical Trial; Research Support, U.S. Gov't, P.H.S.; Research Support, Non-U.S. Gov't; Randomized Controlled Trial; Journal Article

DOI: 10.1007/s002130000657

PMID: 11401006

Source access – 23 October 2026: Direct retrieval could not be fully verified; availability remains unresolved.

Bibliographic attribution or source identity cross-checked.

DOI – publisher access (access restrictions may apply)

[V5_US_LABEL_2026] EPIDIOLEX (cannabidiol) oral solution – US Prescribing Information, revised 5/2026

Original source / bibliographic reference

Authors: Jazz Pharmaceuticals, Inc. / DailyMed

Year: 2026

Source type: Regulatory US product information; not an additional independent clinical study

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

Research as of 23 October 2026. Not all original full texts could be reviewed in full. Source accessibility and the strength of scientific evidence must be assessed separately. An accessible link does not establish medical approval; a bibliographic record with an abstract does not replace the original full text.

Drug search and explanation of the evidence · Guide: cannabinoids and medicines · Author and responsibility