Ampicillin

For an informed discussion with your doctor or pharmacist. This information collection is not a clinically validated interaction checker. Missing data do not establish safety. Do not change or stop prescribed medicines on the basis of this information. The findings apply to the specific conditions studied; laboratory and animal studies cannot be directly extrapolated to humans.

Active substance: Ampicillin

Examples of brand names: Binotal [DE]

ATC code: J01CA01

Main use (for orientation): Bacterial infections

Documented research summary

A laboratory experiment with Salmonella typhimurium reports combination synergy. The starting material is a commercial crude CBD extract, not analytically documented pure CBD. No clinical pharmacokinetic or safety measurement.

Uncertainties and limitations

No quantitative cannabinoid profile of the crude extract in the assessed methods; the concentration nominally stated as CBD does not establish isolate purity. No therapeutic recommendation. Missing data do not establish safety.

Separately recorded findings

1 separately recorded finding. Each statement applies to its documented study context.

Crude CBD extract; composition not quantitatively established – laboratory and animal studies

Finding ID: B0446

Type of result: Pharmacodynamics; antimicrobial combination with an extract

Observation: Reported FICI of 0.3 classified as synergy.

Mechanism: Enhanced growth inhibition of Salmonella typhimurium in a checkerboard experiment

Study type: In-vitro bacterial experiment

Context studied: Ampicillin 0.5 µg/ml plus nominally 1 µg/ml CBD extract; commercial CO2-extracted/winterised crude extract, not a demonstrated CBD isolate.

Clinical interpretation: Laboratory finding without a clinical combination recommendation; explicitly consider extract limitations.

Limitations and uncertainties: No quantitative cannabinoid profile in the assessed methods; effect cannot reliably be attributed to CBD alone. No human pharmacokinetic, toxicity or efficacy study.

Original sources for this finding: Cannabis sativa CBD Extract Exhibits Synergy with Broad-Spectrum Antibiotics against Salmonella enterica subsp. Enterica serovar typhimurium. [VE_MED_36557613]

References and access status

[VE_LABEL_D0283] AMPICILLIN (AMPICILLIN SODIUM) INJECTION, POWDER, FOR SOLUTION [NORTHSTAR RX, LLC]

Original source / bibliographic reference

Authors: Respective marketing authorisation holder; regulatory product information

Year: 2026

Source type: Product information / SmPC / US Prescribing Information

Source access – 23 October 2026: Source destination was accessible when checked.

Bibliographic attribution or source identity cross-checked.

[VE_MED_36557613] Cannabis sativa CBD Extract Exhibits Synergy with Broad-Spectrum Antibiotics against Salmonella enterica subsp. Enterica serovar typhimurium.

Original source / bibliographic reference

Authors: Gildea L, Ayariga JA, Xu J, Villafane R, Robertson BK, Samuel-Foo M, Ajayi OS.

Year: 2022

Source type: research-article; Journal Article

DOI: 10.3390/microorganisms10122360

PMID: 36557613

Source access – 23 October 2026: Automated direct retrieval was restricted; this does not establish that the link is broken.

Bibliographic attribution or source identity cross-checked.

PubMed – bibliographic reference / abstract

PubMed Central – full-text access according to the literature database – Archive attribution confirmed by Europe PMC metadata. Direct retrieval was not fully verified here; access may require a browser check.

Europe PMC – full-text access according to the literature database – Listed as freely available HTML full text in the official Europe PMC metadata. Direct retrieval was not fully verified here.

Research as of 23 October 2026. Not all original full texts could be reviewed in full. Source accessibility and the strength of scientific evidence must be assessed separately. An accessible link does not establish medical approval; a bibliographic record with an abstract does not replace the original full text.

Drug search and explanation of the evidence · Guide: cannabinoids and medicines · Author and responsibility